Western Blot (WB)
(Western blot analysis of extracts from 3T3 cells, treated with etoposide (25uM, 24hours), using ITGA5 (heavy chain, Cleaved-Phe42) antibody.)
anti-Human, Mouse ITGA5 Antibody | anti-ITGA5 antibody
ITGA5 (heavy chain, Cleaved-Phe42) Antibody
ELISA: 1:10000
Western Blot (WB)
(Western blot analysis of extracts from 3T3 cells, treated with etoposide (25uM, 24hours), using ITGA5 (heavy chain, Cleaved-Phe42) antibody.)
Western Blot (WB)
(Western blot analysis of extracts from 3T3 cells, treated with etoposide (25uM, 24hours), using ITGA5 (heavy chain, Cleaved-Phe42) antibody.)
NCBI and Uniprot Product Information
NCBI Description
The product of this gene belongs to the integrin alpha chain family. Integrins are heterodimeric integral membrane proteins composed of an alpha subunit and a beta subunit that function in cell surface adhesion and signaling. The encoded preproprotein is proteolytically processed to generate light and heavy chains that comprise the alpha 5 subunit. This subunit associates with the beta 1 subunit to form a fibronectin receptor. This integrin may promote tumor invasion, and higher expression of this gene may be correlated with shorter survival time in lung cancer patients. Note that the integrin alpha 5 and integrin alpha V subunits are encoded by distinct genes. [provided by RefSeq, Oct 2015]
Uniprot Description
Integrin alpha-5/beta-1 is a receptor for fibronectin and fibrinogen. It recognizes the sequence R-G-D in its ligands. ITGA5:ITGB1 binds to PLA2G2A via a site (site 2) which is distinct from the classical ligand-binding site (site 1) and this induces integrin conformational changes and enhanced ligand binding to site 1 (PubMed:18635536, PubMed:25398877). ITGA5:ITGB1 acts as a receptor for fibrillin-1 (FBN1) and mediates R-G-D-dependent cell adhesion to FBN1 (PubMed:12807887, PubMed:17158881).
Research Articles on ITGA5
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Product Notes
The ITGA5 itga5 (Catalog #AAA855387) is an Antibody and is intended for research purposes only. The product is available for immediate purchase. The ITGA5 (heavy chain, Cleaved-Phe42) Antibody reacts with Human, Mouse and may cross-react with other species as described in the data sheet. AAA Biotech's ITGA5 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), ELISA (EIA). WB: 1:500-1:1000 ELISA: 1:10000. Researchers should empirically determine the suitability of the ITGA5 itga5 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "ITGA5, Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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