Human Tyrosine Aminotransferase (TAT) ELISA Kit | TAT elisa kit

Human Tyrosine Aminotransferase (TAT) ELISA Kit

Cat. Num. AAA9311490

• Reactivity: Human
• Synonyms: Tyrosine Aminotransferase (TAT); Human Tyrosine Aminotransferase (TAT) ELISA Kit; TAT elisa kit

• Reactivity: Human

• Preparation and Storage: Store all reagents at 2-8 degree C

NCBI and Uniprot Product Information

• NCBI GI #: 4507369
• NCBI GeneID: 6898
• NCBI Accession #: NP_000344.1
• NCBI GenBank Nucleotide #: NM_000353.2
• UniProt Accession #: P17735; B2R8I1; D3DWS2
• Molecular Weight: 50,399 Da
• NCBI Official Full Name: tyrosine aminotransferase
• NCBI Official Synonym Full Names: tyrosine aminotransferase
• NCBI Official Symbol: TAT
• NCBI Protein Information: tyrosine aminotransferase; tyrosine aminotransferase, cytosolic; L-tyrosine:2-oxoglutarate aminotransferase
• UniProt Protein Name: Tyrosine aminotransferase
• Protein Family: Tyrosine aminotransferase
• UniProt Gene Name: TAT
• UniProt Synonym Gene Names: TAT
• UniProt Entry Name: ATTY_HUMAN

NCBI Description

This nuclear gene encodes a mitochondrial protein tyrosine aminotransferase which is present in the liver and catalyzes the conversion of L-tyrosine into p-hydroxyphenylpyruvate. Mutations in this gene cause tyrosinemia (type II, Richner-Hanhart syndrome), a disorder accompanied by major skin and corneal lesions, with possible mental retardation. A regulator gene for tyrosine aminotransferase is X-linked. [provided by RefSeq, Jul 2008]

Uniprot Description

TAT: Transaminase involved in tyrosine breakdown. Converts tyrosine to p-hydroxyphenylpyruvate. Can catalyze the reverse reaction, using glutamic acid, with 2-oxoglutarate as cosubstrate (in vitro). Has much lower affinity and transaminase activity towards phenylalanine. Defects in TAT are the cause of tyrosinemia type 2 (TYRO2); also known as Richner-Hanhart syndrome. TYRO2 is an inborn error of metabolism characterized by elevations of tyrosine in the blood and urine, and oculocutaneous manifestations. Typical features include palmoplantar keratosis, painful corneal ulcers, and mental retardation. Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

Protein type: Amino Acid Metabolism - phenylalanine, tyrosine and tryptophan biosynthesis; Transferase; EC 2.6.1.5; Amino Acid Metabolism - cysteine and methionine; Amino Acid Metabolism - tyrosine; Amino Acid Metabolism - phenylalanine; Cofactor and Vitamin Metabolism - ubiquinone and other terpenoid-quinone biosynthesis; Mitochondrial

Chromosomal Location of Human Ortholog: 16q22.1

Cellular Component: mitochondrion; cytosol

Molecular Function: amino acid binding; tyrosine transaminase activity; pyridoxal phosphate binding

Biological Process: response to mercury ion; glutamate metabolic process; L-phenylalanine catabolic process; tyrosine catabolic process; response to glucocorticoid stimulus; biosynthetic process; response to oxidative stress; 2-oxoglutarate metabolic process

Disease: Tyrosinemia, Type Ii