Human Tumor necrosis factor alpha-induced protein 8-like protein 2 (TNFAIP8L2) ELISA Kit | TNFAIP8L2 elisa kit

Human Tumor necrosis factor alpha-induced protein 8-like protein 2 (TNFAIP8L2) ELISA Kit

Cat. Num. AAA2801602

• Gene Names: TNFAIP8L2; TIPE2
• Reactivity: Human
• Synonyms: Tumor necrosis factor alpha-induced protein 8-like protein 2 (TNFAIP8L2); Human Tumor necrosis factor alpha-induced protein 8-like protein 2 (TNFAIP8L2) ELISA Kit; RP11-68I18.4; FLJ23467; TIPE2; inflammation factor 20; TNFAIP8L2 elisa kit

• Reactivity: Human
• Specificity: This assay has high sensitivity and excellent specificity for detection of Human TNFAIP8L2. No significant cross-reactivity or interference between Human TNFAIP8L2 and analogues was observed.

• Asssay Type: Quantitive Sandwich
• Sample Types: Serum, Plasma, Other biological fluids
• Detection Wavelength: 450nm
• Sample Volume: 1-200uL
• Precision: Intra-assay Precision (Precision within an assay): Three samples of known concentration were tested twenty times on one plate to assess intra-assay precision.; Inter-assay Precision (Precision between assays): Three samples of known concentration were tested in forty separate assays to assess inter-assay precision.; CV (%) = SD/meanX100; Intra-Assay: CV<8%; Inter-Assay: CV<12%
• Test Principle: This assay employs a two-site sandwich ELISA to quantitate TNFAIP8L2 in samples. An antibody specific for TNFAIP8L2 has been pre-coated onto a microplate. Standards and samples are pipetted into the wells and anyTNFAIP8L2 present is bound by the immobilized antibody. After removing any unbound substances, a biotin-conjugated antibody specific for TNFAIP8L2 is added to the wells. After washing, Streptavidin conjugated Horseradish Peroxidase (HRP) is added to the wells. Following a wash to remove any unbound avidin-enzyme reagent, a substrate solution is added to the wells and color develops in proportion to the amount of TNFAIP8L2 bound in the initial step. The color development is stopped and the intensity of the color is measured.
• Assay Duration: 1-4.5h
• Preparation and Storage: Store at 2-8 degree C

NCBI and Uniprot Product Information

• NCBI GI #: 157389001
• NCBI GeneID: 79626
• NCBI Accession #: NP_078851.2
• NCBI GenBank Nucleotide #: NM_024575.4
• UniProt Accession #: Q6P589; Q6I9Y0; Q9H2H7; Q9H5G2
• Molecular Weight: 20,556 Da
• NCBI Official Full Name: tumor necrosis factor alpha-induced protein 8-like protein 2
• NCBI Official Synonym Full Names: tumor necrosis factor, alpha-induced protein 8-like 2
• NCBI Official Symbol: TNFAIP8L2
• NCBI Official Synonym Symbols: TIPE2
• NCBI Protein Information: tumor necrosis factor alpha-induced protein 8-like protein 2; TNFAIP8-like protein 2; inflammation factor 20; inflammation factor protein 20; TNF alpha-induced protein 8-like protein 2; tumor necrosis factor, alpha-induced protein 8-like protein 2
• UniProt Protein Name: Tumor necrosis factor alpha-induced protein 8-like protein 2
• Protein Family: Tumor necrosis factor alpha-induced protein 8-like protein
• UniProt Gene Name: TNFAIP8L2
• UniProt Synonym Gene Names: TIPE2; TNF alpha-induced protein 8-like protein 2
• UniProt Entry Name: TP8L2_HUMAN

Uniprot Description

TNFAIP8L2: Acts as a negative regulator of innate and adaptive immunity by maintaining immune homeostasis. Negative regulator of Toll-like receptor and T-cell receptor function. Prevents hyperresponsiveness of the immune system and maintains immune homeostasis. Inhibits JUN/AP1 and NF-kappa-B activation. Promotes Fas-induced apoptosis. Belongs to the TNFAIP8 family. TNFAIP8L2 subfamily.

Chromosomal Location of Human Ortholog: 1q21.3

Cellular Component: cytoplasm

Molecular Function: protein binding

Biological Process: negative regulation of inflammatory response; innate immune response; negative regulation of T cell activation