Human Transcription Intermediary Factor 1-Beta (TRIM28) ELISA Kit | TRIM28 elisa kit
Human Transcription Intermediary Factor 1-Beta (TRIM28) ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene mediates transcriptional control by interaction with the Kruppel-associated box repression domain found in many transcription factors. The protein localizes to the nucleus and is thought to associate with specific chromatin regions. The protein is a member of the tripartite motif family. This tripartite motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. [provided by RefSeq, Jul 2008]
Uniprot Description
TIF1B: an atypical protein kinase that functions as a transcriptional coactivator. Mediates transcriptional regulation by interaction with the Kruppel-associated box (KRAB) repression domain found in many transcription factors. Binds to the negative regulatory domain of c-Myb and negatively regulates the c-Myb-dependent trans-activation. Localizes to the nucleus and is thought to associate with specific chromatin regions. Phosphorylated in an ATM-dependent manner following double-strand breaks. Its phosphorylation in response to DNA damage leads to chromatin relaxation. A member of the tripartite motif family. The tripartite motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region.
Protein type: ATYPICAL group; EC 6.3.2.-; Kinase, protein; Ligase; Nuclear receptor co-regulator; Protein kinase, atypical; TIF1 family; Transcription, coactivator/corepressor; Ubiquitin conjugating system; Ubiquitin ligase
Chromosomal Location of Human Ortholog: 19q13.43
Cellular Component: nuclear euchromatin; nuclear heterochromatin; nucleoplasm; nucleus; RNA polymerase II transcription factor complex
Molecular Function: chromatin binding; chromo shadow domain binding; DNA binding; DNA binding transcription factor activity; promoter-specific chromatin binding; protein binding; protein kinase activity; RNA binding; sequence-specific DNA binding; transcription corepressor activity; ubiquitin protein ligase binding; ubiquitin-protein transferase activity; zinc ion binding
Biological Process: convergent extension involved in axis elongation; covalent chromatin modification; DNA methylation involved in embryo development; DNA repair; embryo implantation; epithelial to mesenchymal transition; innate immune response; negative regulation of DNA demethylation; negative regulation of retroviral genome replication; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; negative regulation of viral release from host cell; positive regulation of DNA binding; positive regulation of DNA repair; positive regulation of methylation-dependent chromatin silencing; positive regulation of transcription factor import into nucleus; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-templated; protein autophosphorylation; protein oligomerization; protein sumoylation; protein ubiquitination; Ras protein signal transduction; regulation of genetic imprinting; transcription initiation from RNA polymerase II promoter
Research Articles on TRIM28
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Product Notes
The Human TRIM28 trim28 (Catalog #AAA9902706) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9902706 ELISA Kit recognizes Human TRIM28. It is sometimes possible for the material contained within the vial of "Transcription Intermediary Factor 1-Beta (TRIM28), ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
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