Human TIMP-2 ELISA Kit | TIMP-2 elisa kit

TIMP-2 (Human) OmniKine ELISA Kit

Cat. Num. AAA9501993

• Gene Names: TIMP2; DDC8; CSC-21K
• Reactivity: Human
• Synonyms: TIMP-2; TIMP-2 (Human) OmniKine ELISA Kit; Metalloproteinase inhibitor 2; CSC-21K; Tissue inhibitor of metalloproteinases 2; TIMP-2 elisa kit

• Reactivity: Human
• Specificity: The OmniKine Human TIMP-2 ELISA is capable of recognizing both recombinant and naturally produced Human TIMP-2 proteins. The antigens listed below were tested at 50 ng/ml and did not exhibit significant cross reactivity or interference.; Human: TIMP-1, TIMP-3; Murine: TIMP-1; Rat: TIMP-1
• Form/Format: 12 x 8-Well Microstrips
• Sequence Length: 220

• Samples: Plasma, serum, lysate
• Assay Type: Sandwich ELISA
• Detection Range: 32-2000 pg/ml
• Sensitivity: 32-2000 pg/ml
• Detection Method: Colorimetric 450 nm
• Subtype: None
• Preparation and Storage: Store at 4 degree C for 6 months.

Testing Data

(The OmniKine Human TIMP-2 ELISA Kit allows for the detection and quantification of endogenous levels of natural and/or recombinant Human TIMP-2 proteins within the range of 32-2000 pg/ml.)

NCBI and Uniprot Product Information

• NCBI GI #: 4507511
• NCBI GeneID: 7077
• NCBI Accession #: NP_003246.1
• NCBI GenBank Nucleotide #: NM_003255.4
• UniProt Accession #: P16035; Q16121; Q93006; Q9UDF7
• Molecular Weight: 24,399 Da
• NCBI Official Full Name: metalloproteinase inhibitor 2
• NCBI Official Synonym Full Names: TIMP metallopeptidase inhibitor 2
• NCBI Official Symbol: TIMP2
• NCBI Official Synonym Symbols: DDC8; CSC-21K
• NCBI Protein Information: metalloproteinase inhibitor 2
• UniProt Protein Name: Metalloproteinase inhibitor 2
• UniProt Gene Name: TIMP2
• UniProt Synonym Gene Names: TIMP-2

NCBI Description

This gene is a member of the TIMP gene family. The proteins encoded by this gene family are natural inhibitors of the matrix metalloproteinases, a group of peptidases involved in degradation of the extracellular matrix. In addition to an inhibitory role against metalloproteinases, the encoded protein has a unique role among TIMP family members in its ability to directly suppress the proliferation of endothelial cells. As a result, the encoded protein may be critical to the maintenance of tissue homeostasis by suppressing the proliferation of quiescent tissues in response to angiogenic factors, and by inhibiting protease activity in tissues undergoing remodelling of the extracellular matrix. [provided by RefSeq, Jul 2008]

Uniprot Description

TIMP2: Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. Known to act on MMP-1, MMP-2, MMP-3, MMP-7, MMP-8, MMP-9, MMP-10, MMP-13, MMP-14, MMP-15, MMP-16 and MMP-19. Interacts (via the C-terminal) with MMP2 (via the C- terminal PEX domain); the interaction inhibits the MMP2 activity. Down-regulated by TGFB1. Belongs to the protease inhibitor I35 (TIMP) family.

Protein type: Cell development/differentiation; Extracellular matrix; Inhibitor; Motility/polarity/chemotaxis; Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 17q25.3

Cellular Component: cell soma; cell surface; extracellular matrix; extracellular region; extracellular space; growth cone; proteinaceous extracellular matrix

Molecular Function: integrin binding; metalloendopeptidase inhibitor activity; protease binding; protein binding; zinc ion binding

Biological Process: aging; central nervous system development; extracellular matrix disassembly; negative regulation of cell proliferation; negative regulation of membrane protein ectodomain proteolysis; negative regulation of mitotic cell cycle; negative regulation of Ras protein signal transduction; neutrophil degranulation; positive regulation of adenylate cyclase activity; positive regulation of MAPK cascade; positive regulation of neuron differentiation; regulation of Rap protein signal transduction; response to cytokine; response to drug; response to hormone