Human stromal cell derived factor-1alpha (SDF-1alpha) ELISA Kit | SDF-1alpha elisa kit
Human stromal cell derived factor-1alpha (SDF-1alpha) ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
This gene encodes the substrate of breast tumor kinase, an Src-type non-receptor tyrosine kinase. The encoded protein possesses domains and several tyrosine phosphorylation sites characteristic of adaptor proteins that mediate the interactions linking proteins involved in signal transduction pathways. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2008]
Uniprot Description
STAP2: a widely expressed proimflammatory adaptor protein that regulates immune and inflammatory responses. Binds and modulates a variety of molecules including Brk, CSFR, FCER1, and BCR-ABL. The interaction between STAP-2 and BCR-ABL appears to provide a growth advantage to BCR-ABL+ chronic myeloid leukemia cells. Suppression of STAP-2 expression in K562 CML cells suppressed tumor formation in mice. Enables intestinal proinflammatory responses in vivo: promotes macrophage recruitment in dextran sodium sulfate induced colitis, and promotes the ability of CXCL12-induced migration in macrophages. STAP-2 knockdown in T47D breast cancer cells induced a significant decrease of proliferation. Contains a pleckstrin homology, Src homology 2-like, and as well as a STAT3-binding domains. Two isoforms of the human protein are produced by alternative splicing.
Protein type: Adaptor/scaffold
Chromosomal Location of Human Ortholog: 19p13.3
Cellular Component: cytoplasm; plasma membrane
Molecular Function: protein binding
Research Articles on SDF-1alpha
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Product Notes
The Human SDF-1alpha stap2 (Catalog #AAA269465) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA269465 ELISA Kit recognizes Human SDF-1alpha. It is sometimes possible for the material contained within the vial of "stromal cell derived factor-1alpha (SDF-1alpha), ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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