Human Ski oncogene (SKI) ELISA Kit | SKI elisa kit
Human Ski oncogene (SKI) ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
This gene encodes the nuclear protooncogene protein homolog of avian sarcoma viral (v-ski) oncogene. It functions as a repressor of TGF-beta signaling, and may play a role in neural tube development and muscle differentiation. [provided by RefSeq, Oct 2009]
Uniprot Description
SKI: May play a role in terminal differentiation of skeletal muscle cells but not in the determination of cells to the myogenic lineage. Functions as a repressor of TGF-beta signaling. Belongs to the SKI family.
Protein type: Ubiquitin conjugating system; Oncoprotein; Transcription, coactivator/corepressor; Cell cycle regulation
Chromosomal Location of Human Ortholog: 1p36.33
Cellular Component: nucleoplasm; nuclear body; centrosome; PML body; transcription factor complex; protein complex; transcriptional repressor complex; cytoplasm; nucleus
Molecular Function: protein domain specific binding; histone deacetylase inhibitor activity; protein binding; zinc ion binding; ubiquitin protein ligase binding; chromatin binding; SMAD binding; protein kinase binding; transcription corepressor activity
Biological Process: somatic stem cell maintenance; cell motility involved in cell locomotion; skeletal muscle fiber development; negative regulation of transcription from RNA polymerase II promoter; palate development; negative regulation of BMP signaling pathway; regulation of apoptosis; nose morphogenesis; BMP signaling pathway; negative regulation of cell proliferation; transforming growth factor beta receptor signaling pathway; negative regulation of osteoblast differentiation; positive regulation of Wnt receptor signaling pathway; embryonic limb morphogenesis; positive regulation of DNA binding; transcription initiation from RNA polymerase II promoter; negative regulation of histone deacetylation; camera-type eye development; transcription, DNA-dependent; olfactory bulb development; myotube differentiation; myelination in the peripheral nervous system; negative regulation of activin receptor signaling pathway; cell proliferation; camera-type eye morphogenesis; retina development in camera-type eye; negative regulation of fibroblast proliferation; neural tube closure; gene expression; lens morphogenesis in camera-type eye; positive regulation of transcription from RNA polymerase II promoter; negative regulation of transforming growth factor beta receptor signaling pathway; anterior/posterior axis specification
Disease: Shprintzen-goldberg Craniosynostosis Syndrome
Research Articles on SKI
Similar Products
Product Notes
The Human SKI ski (Catalog #AAA7202664) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA7202664 ELISA Kit recognizes Human SKI. It is sometimes possible for the material contained within the vial of "Ski oncogene (SKI), ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.
