Human Signal-Induced Proliferation-Associated Protein-1 (SPA-1/SIPA-1) ELISA Kit | SPA-1/SIPA-1 elisa kit

Human Signal-Induced Proliferation-Associated Protein-1 (SPA-1/SIPA-1) ELISA Kit

Cat. Num. AAA3801501

• Gene Names: SIPA1; SPA1
• Reactivity: Human
• Synonyms: Signal-Induced Proliferation-Associated Protein-1 (SPA-1/SIPA-1); Human Signal-Induced Proliferation-Associated Protein-1 (SPA-1/SIPA-1) ELISA Kit; SPA-1/SIPA-1 elisa kit

• Reactivity: Human
• Sequence Length: 1042

• Samples: Serum, plasma, cell culture supernate and other biological fluids
• Assay Type: Sandwich
• Detection Range: 100 pg/ml-1600 pg/ml
• Sensitivity: 10 pg/ml

Typical Testing Data/Standard Curve (for reference only)

Related Product Information for SPA-1/SIPA-1 elisa kit

Intended Use: The Stop Solution changes the color from blue to yellow and the intensity of the color is measured at 450 nm using a spectrophotometer. In order to measure the concentration ofSPA-1;SIPA-1in the sample, This SPA-1;SIPA-1ELISA Kit includes a set of calibration standards. The calibration standards are assayed at the same time as the samples and allow the operator to produce a standard curve of Optical Density versusSPA-1;SIPA-1concentration. The concentration ofSPA-1;SIPA-1in the samples is then determined by comparing the O.D. of the samples to the standard curve.

NCBI and Uniprot Product Information

• NCBI GI #: 206725526
• NCBI GeneID: 6494
• NCBI GenBank Nucleotide #: NP_694985.29
• UniProt Accession #: Q96FS4
• NCBI Official Full Name: signal-induced proliferation-associated protein 1
• NCBI Official Synonym Full Names: signal-induced proliferation-associated 1
• NCBI Official Symbol: SIPA1
• NCBI Official Synonym Symbols: SPA1
• NCBI Protein Information: signal-induced proliferation-associated protein 1
• UniProt Protein Name: Signal-induced proliferation-associated protein 1
• UniProt Gene Name: SIPA1
• UniProt Synonym Gene Names: SPA1; Sipa-1
• UniProt Entry Name: SIPA1_HUMAN

NCBI Description

The product of this gene is a mitogen induced GTPase activating protein (GAP). It exhibits a specific GAP activity for Ras-related regulatory proteins Rap1 and Rap2, but not for Ran or other small GTPases. This protein may also hamper mitogen-induced cell cycle progression when abnormally or prematurely expressed. It is localized to the perinuclear region. Two alternatively spliced variants encoding the same isoform have been characterized to date. [provided by RefSeq, Jul 2008]

Uniprot Description

SIPA1: GTPase activator for the nuclear Ras-related regulatory proteins Rap1 and Rap2 in vitro, converting it to the putatively inactive GDP-bound state.

Protein type: GAPs, Ras; GAPs

Chromosomal Location of Human Ortholog: 11q13

Cellular Component: Golgi apparatus; transport vesicle; protein complex; perinuclear region of cytoplasm; nucleolus; plasma membrane; cytosol; nucleus

Molecular Function: protein C-terminus binding; protein binding; GTPase activator activity

Biological Process: cell proliferation; cellular response to water deprivation; cytoskeleton organization and biogenesis; negative regulation of cell adhesion; negative regulation of cell growth; signal transduction; negative regulation of cell cycle; positive regulation of GTPase activity