Human Sal-Like Protein 4 (SALL4) ELISA Kit | SALL4 elisa kit

Human Sal-Like Protein 4 (SALL4) ELISA Kit

Cat. Num. AAA3802776

• Gene Names: SALL4; DRRS; HSAL4; ZNF797
• Reactivity: Human
• Synonyms: Sal-Like Protein 4 (SALL4); Human Sal-Like Protein 4 (SALL4) ELISA Kit; SALL4 elisa kit

• Reactivity: Human
• Sequence Length: 1053

• Sensitivity: 0.1ng/ml
• Intra-assay Precision: Intra-assay CV is less than 15%.
• Inter-assay Precision: Inter-assay CV is less than 15%.

Typical Testing Data/Standard Curve (for reference only)

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Related Product Information for SALL4 elisa kit

Intended Uses: This SALL4 is intended Laboratory for Research use only. The Stop Solution changes the color from blue to yellow and the intensity of the color is measured at 450 nm using a spectrophotometer. In order to measure the concentration of SALL4 in the sample, this SALL4 includes a set of calibration standards. The calibration standards are assayed at the same time as the samples and allow the operator to produce a standard curve of Optical Density versus SALL4 concentration. The concentration of SALL4 in the samples is then determined by comparing the O.D. of the samples to the standard curve.

NCBI and Uniprot Product Information

• NCBI GI #: 10047144
• NCBI GeneID: 57167
• NCBI GenBank Nucleotide #: NP_065169.1
• UniProt Accession #: Q9UJQ4
• NCBI Official Full Name: sal-like protein 4 isoform 1
• NCBI Official Synonym Full Names: spalt like transcription factor 4
• NCBI Official Symbol: SALL4
• NCBI Official Synonym Symbols: DRRS; HSAL4; ZNF797
• NCBI Protein Information: sal-like protein 4
• UniProt Protein Name: Sal-like protein 4
• Protein Family: Sal-like protein
• UniProt Gene Name: SALL4
• UniProt Synonym Gene Names: ZNF797
• UniProt Entry Name: SALL4_HUMAN

NCBI Description

This gene encodes a zinc finger transcription factor thought to play a role in the development of abducens motor neurons. Defects in this gene are a cause of Duane-radial ray syndrome (DRRS). Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2015]

Uniprot Description

SALL4: a transcription factor and oncofetal protein expressed embryonically and in the testis. Plays a key role in maintenance and self-renewal of embryonic stem cells. Interacts with NANOG and OCT4. Ectopically expressed in acute B-cell lymphoblastic leukemia (B-ALL) and myeloid leukemia (AML), playing a role in the survival of B-ALL cells and in myeloid leukemogenesis. Aberrantly expressed in multiple carcinomas including human gastric carcinoma and hepatocellular carcinoma. Maintains the stem cell qualities of EpCAM-positive hepatocellular carcinoma cells. Expressed in primary human endometrial cancer samples but not normal or hyperplastic endometrial cells. Its expression in carcinomas positively correlates with metastatic potential and poor patient survival. Specifically binds the c-Myc promoter region in endometrial cancer cells, apparently increasing c-Myc expression. Belongs to the sal C2H2-type zinc-finger protein family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Cancer Testis Antigen (CTA); DNA-binding; C2H2-type zinc finger protein

Chromosomal Location of Human Ortholog: 20q13.2

Cellular Component: nucleoplasm; heterochromatin; protein complex; intracellular membrane-bound organelle; cytoplasm

Molecular Function: DNA binding; metal ion binding

Biological Process: transcription, DNA-dependent; somatic stem cell maintenance; neural tube closure; positive regulation of transcription from RNA polymerase II promoter; negative regulation of transcription from RNA polymerase II promoter; inner cell mass cell proliferation; embryonic limb morphogenesis

Disease: Ivic Syndrome; Duane-radial Ray Syndrome