Human Receptor Activator Of Nuclear Factor Kappa B Ligand (RANkL) ELISA Kit | RANkL elisa kit
Human Receptor Activator Of Nuclear Factor Kappa B Ligand (RANkL) Mini Samples ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a member of the tumor necrosis factor (TNF) cytokine family which is a ligand for osteoprotegerin and functions as a key factor for osteoclast differentiation and activation. This protein was shown to be a dentritic cell survival factor and is involved in the regulation of T cell-dependent immune response. T cell activation was reported to induce expression of this gene and lead to an increase of osteoclastogenesis and bone loss. This protein was shown to activate antiapoptotic kinase AKT/PKB through a signaling complex involving SRC kinase and tumor necrosis factor receptor-associated factor (TRAF) 6, which indicated this protein may have a role in the regulation of cell apoptosis. Targeted disruption of the related gene in mice led to severe osteopetrosis and a lack of osteoclasts. The deficient mice exhibited defects in early differentiation of T and B lymphocytes, and failed to form lobulo-alveolar mammary structures during pregnancy. Two alternatively spliced transcript variants have been found. [provided by RefSeq, Jul 2008]
Uniprot Description
TNFSF11: Cytokine that binds to TNFRSF11B/OPG and to TNFRSF11A/RANK. Osteoclast differentiation and activation factor. Augments the ability of dendritic cells to stimulate naive T-cell proliferation. May be an important regulator of interactions between T-cells and dendritic cells and may play a role in the regulation of the T-cell-dependent immune response. May also play an important role in enhanced bone-resorption in humoral hypercalcemia of malignancy. Homotrimer. Up-regulated by T-cell receptor stimulation. Highest in the peripheral lymph nodes, weak in spleen, peripheral blood Leukocytes, bone marrow, heart, placenta, skeletal muscle, stomach and thyroid. Belongs to the tumor necrosis factor family. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, integral
Chromosomal Location of Human Ortholog: 13q14.11
Cellular Component: extracellular region; plasma membrane
Molecular Function: cytokine activity; tumor necrosis factor receptor superfamily binding
Biological Process: activation of NF-kappaB transcription factor; calcium-mediated signaling; cytokine and chemokine mediated signaling pathway; monocyte chemotaxis; osteoclast differentiation; positive regulation of bone resorption; positive regulation of corticotropin-releasing hormone secretion; positive regulation of homotypic cell-cell adhesion; positive regulation of MAP kinase activity; positive regulation of osteoclast differentiation; positive regulation of T cell activation; positive regulation of transcription factor activity; positive regulation of transcription from RNA polymerase II promoter; tumor necrosis factor-mediated signaling pathway
Disease: Osteopetrosis, Autosomal Recessive 2
Research Articles on RANkL
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Product Notes
The Human RANkL tnfsf11 (Catalog #AAA2087656) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA2087656 ELISA Kit recognizes Human RANkL. It is sometimes possible for the material contained within the vial of "Receptor Activator Of Nuclear Factor Kappa B Ligand (RANkL), ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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