Human Preferentially Expressed Antigen In Melanoma (PRAME) ELISA Kit | PRAME elisa kit
Human Preferentially Expressed Antigen In Melanoma (PRAME) Mini Samples ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
This gene encodes an antigen that is preferentially expressed in human melanomas and that is recognized by cytolytic T lymphocytes. It is not expressed in normal tissues, except testis. The encoded protein acts as a repressor of retinoic acid receptor, and likely confers a growth advantage to cancer cells via this function. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2014]
Uniprot Description
PRAME: Functions as a transcriptional repressor, inhibiting the signaling of retinoic acid through the retinoic acid receptors RARA, RARB and RARG. Prevents retinoic acid-induced cell proliferation arrest, differentiation and apoptosis. Belongs to the PRAME family.
Protein type: Cancer Testis Antigen (CTA); Nuclear receptor co-regulator; Transcription, coactivator/corepressor
Chromosomal Location of Human Ortholog: 22q11.22
Molecular Function: protein binding; retinoic acid receptor binding
Biological Process: negative regulation of apoptosis; negative regulation of cell differentiation; negative regulation of retinoic acid receptor signaling pathway; negative regulation of transcription, DNA-dependent; positive regulation of cell proliferation
Research Articles on PRAME
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Product Notes
The Human PRAME prame (Catalog #AAA2088070) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA2088070 ELISA Kit recognizes Human PRAME. It is sometimes possible for the material contained within the vial of "Preferentially Expressed Antigen In Melanoma (PRAME), ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
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