Human Phosphotidylinositol phosphatase PTPRQ ELISA Kit | PTPRQ elisa kit
Human Phosphotidylinositol phosphatase PTPRQ ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
This locus encodes a member of the type III receptor-like protein-tyrosine phosphatase family. The encoded protein catalyzes the dephosphorylation of phosphotyrosine and phosphatidylinositol and plays roles in cellular proliferation and differentiation. Mutations at this locus have been linked to autosomal recessive deafness. [provided by RefSeq, Mar 2014]
Uniprot Description
PTPRQ: Phosphatidylinositol phosphatase required for auditory function. May act by regulating the level of phosphatidylinositol 4,5-bisphosphate (PIP2) level in the basal region of hair bundles. Can dephosphorylate a broad range of phosphatidylinositol phosphates, including phosphatidylinositol 3,4,5-trisphosphate and most phosphatidylinositol monophosphates and diphosphates. Phosphate can be hydrolyzed from the D3 and D5 positions in the inositol ring. Has low tyrosine-protein phosphatase activity; however, the relevance of such activity in vivo is unclear. Plays an important role in adipogenesis of mesenchymal stem cells (MSCs). Regulates the phosphorylation state of AKT1 by suppressing the phosphatidylinositol 3,4,5-trisphosphate (PIP3) level in MSCs and preadipocyte cells. Defects in PTPRQ are the cause of deafness autosomal recessive type 84 (DFNB84). DFNB84 is a form of non- syndromic deafness characterized by progressive, sensorineural hearing loss and vestibular dysfunction. Belongs to the protein-tyrosine phosphatase family. Receptor class 2A subfamily.
Protein type: EC 3.1.3.48; Membrane protein, integral; Phosphatase, lipid; Receptor protein phosphatase, tyrosine
Chromosomal Location of Human Ortholog: 12q21.31
Biological Process: regulation of fat cell differentiation
Disease: Deafness, Autosomal Recessive 84a
Research Articles on PTPRQ
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Product Notes
The Human PTPRQ ptprq (Catalog #AAA9426449) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9426449 ELISA Kit recognizes Human PTPRQ. It is sometimes possible for the material contained within the vial of "Phosphotidylinositol phosphatase PTPRQ, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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