Human PAN2 poly (A) specific ribonuclease subunit homolog (S. cerevisiae) ELISA Kit | PAN2 elisa kit
Human PAB-dependent poly, PAN2 ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a deadenylase that functions as the catalytic subunit of the polyadenylate binding protein dependent poly(A) nuclease complex. The encoded protein is a magnesium dependent 3' to 5' exoribonuclease that is involved in the degradation of cytoplasmic mRNAs. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]
Uniprot Description
USP52: Functions in cytoplasmic mRNA decay. As part of the Pan nuclease complex, shortens poly(A) tails of RNA when the poly(A) stretch is bound by polyadenylate-binding protein. Belongs to the peptidase C19 family. PAN2 subfamily. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Ubiquitin-specific protease; Ribonuclease; EC 3.1.13.4
Chromosomal Location of Human Ortholog: 12q13.2
Cellular Component: cytosol; nucleus
Molecular Function: protein binding; 3'-5'-exoribonuclease activity; poly(A)-specific ribonuclease activity; nucleic acid binding
Biological Process: poly(A) tail shortening; gene expression; mRNA catabolic process, deadenylation-dependent decay
Research Articles on PAN2
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Product Notes
The Human PAN2 pan2 (Catalog #AAA9335725) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9335725 ELISA Kit recognizes Human PAN2. It is sometimes possible for the material contained within the vial of "PAN2 poly (A) specific ribonuclease subunit homolog (S. cerevisiae), ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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