Human NUF2, NDC80 kinetochore complex component, homolog (S. cerevisiae) ELISA Kit | NUF2 elisa kit
Human Kinetochore protein Nuf2, NUF2 ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a protein that is highly similar to yeast Nuf2, a component of a conserved protein complex associated with the centromere. Yeast Nuf2 disappears from the centromere during meiotic prophase when centromeres lose their connection to the spindle pole body, and plays a regulatory role in chromosome segregation. The encoded protein is found to be associated with centromeres of mitotic HeLa cells, which suggests that this protein is a functional homolog of yeast Nuf2. Alternatively spliced transcript variants that encode the same protein have been described. [provided by RefSeq, Jul 2008]
Uniprot Description
NUF2: Acts as a component of the essential kinetochore- associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity. Required for kinetochore integrity and the organization of stable microtubule binding sites in the outer plate of the kinetochore. Belongs to the NUF2 family.
Protein type: DNA replication; Cancer Testis Antigen (CTA)
Chromosomal Location of Human Ortholog: 1q23.3
Cellular Component: membrane; nucleus; cytosol; chromosome, pericentric region
Molecular Function: protein binding
Biological Process: mitosis; cell division; mitotic cell cycle; chromosome segregation
Research Articles on NUF2
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Product Notes
The Human NUF2 nuf2 (Catalog #AAA9320187) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9320187 ELISA Kit recognizes Human NUF2. It is sometimes possible for the material contained within the vial of "NUF2, NDC80 kinetochore complex component, homolog (S. cerevisiae), ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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