Human N-Myc-Interactor (NMI) ELISA Kit | NMI elisa kit

Human N-Myc-Interactor (NMI) ELISA Kit

Cat. Num. AAA3804721

• Reactivity: Human
• Synonyms: N-Myc-Interactor (NMI); Human N-Myc-Interactor (NMI) ELISA Kit; NMI elisa kit

• Reactivity: Human
• Sequence Length: 307

• Samples: Serum, plasma, cell culture supernate and other biological fluids
• Assay Type: Sandwich
• Detection Range: 93.75 pg/ml-1500 pg/ml
• Sensitivity: 1 pg/ml

Typical Testing Data/Standard Curve (for reference only)

Related Product Information for NMI elisa kit

Intended Use: The Stop Solution changes the color from blue to yellow and the intensity of the color is measured at 450 nm using a spectrophotometer. In order to measure the concentration ofNMIin the sample, This NMIELISA Kit includes a set of calibration standards. The calibration standards are assayed at the same time as the samples and allow the operator to produce a standard curve of Optical Density versusNMIconcentration. The concentration ofNMIin the samples is then determined by comparing the O.D. of the samples to the standard curve.

NCBI and Uniprot Product Information

• NCBI GI #: 188219599
• NCBI GeneID: 9111
• NCBI GenBank Nucleotide #: NP_004679.2
• UniProt Accession #: Q13287
• NCBI Official Full Name: N-myc-interactor
• NCBI Official Synonym Full Names: N-myc and STAT interactor
• NCBI Official Symbol: NMI
• NCBI Protein Information: N-myc-interactor
• UniProt Protein Name: N-myc-interactor
• Protein Family: N-myc-interactor
• UniProt Gene Name: NMI
• UniProt Synonym Gene Names: Nmi
• UniProt Entry Name: NMI_HUMAN

NCBI Description

NMYC interactor (NMI) encodes a protein that interacts with NMYC and CMYC (two members of the oncogene Myc family), and other transcription factors containing a Zip, HLH, or HLH-Zip motif. The NMI protein also interacts with all STATs except STAT2 and augments STAT-mediated transcription in response to cytokines IL2 and IFN-gamma. The NMI mRNA has low expression levels in all human fetal and adult tissues tested except brain and has high expression in cancer cell line-myeloid leukemias. [provided by RefSeq, Jul 2008]

Uniprot Description

NMI: May be involved in augmenting coactivator protein recruitment to a group of sequence-specific transcription factors. Augments cytokine-mediated STAT transcription. Enhances CBP/p300 coactivator protein recruitment to STAT1 and STAT5. Belongs to the NMI family.

Protein type: Transcription, coactivator/corepressor

Chromosomal Location of Human Ortholog: 2q23

Cellular Component: nucleoplasm; cytoplasm

Molecular Function: protein binding; transcription cofactor activity

Biological Process: transcription from RNA polymerase II promoter; inflammatory response; JAK-STAT cascade