Typical Testing Data/Standard Curve (for reference only)
(Fig.1. Human Myosin-IIIa (MYO3A) Standard Curve.)
Human Myosin-IIIa (MYO3A) ELISA Kit | MYO3A elisa kit
Human Myosin-IIIa (MYO3A) ELISA Kit
* Allow all reagents to warm to room temperature for at least 30 minutes before opening.
* Pre-rinse the pipet tip with reagent, use fresh pipet tips for each sample, standard and reagent to avoid contamination.
* Unused wells must be kept desiccated at 4 degree C in the sealed bag provided.
* Mix Thoroughly is very important for the result. It is recommended using low frequency oscillator or slight hand shaking every 10 minutes.
* It is recommended that all samples and standards be assayed in duplicate or triplicate.
Typical Testing Data/Standard Curve (for reference only)
(Fig.1. Human Myosin-IIIa (MYO3A) Standard Curve.)
Typical Testing Data/Standard Curve (for reference only)
(Fig.1. Human Myosin-IIIa (MYO3A) Standard Curve.)
Background: Myosin-IIIa encoded by MYO3A belongs to the myosin superfamily. Myosins are actin-dependent motor proteins and are categorized into conventional myosins (class II) and unconventional myosins (classes I and III through XV) based on their variable C-terminal cargo-binding domains. Class III myosins, such as this one, have a kinase domain N-terminal to the conserved N-terminal motor domains and are expressed in photoreceptors. Myosin-IIIa encoded by MYO3A plays an important role in hearing in humans. Three different recessive, loss of function mutations in the encoded protein have been shown to cause nonsyndromic progressive hearing loss. Expression of MYO3A is highly restricted, with the strongest expression in retina and cochlea.
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene belongs to the myosin superfamily. Myosins are actin-dependent motor proteins and are categorized into conventional myosins (class II) and unconventional myosins (classes I and III through XV) based on their variable C-terminal cargo-binding domains. Class III myosins, such as this one, have a kinase domain N-terminal to the conserved N-terminal motor domains and are expressed in photoreceptors. The protein encoded by this gene plays an important role in hearing in humans. Three different recessive, loss of function mutations in the encoded protein have been shown to cause nonsyndromic progressive hearing loss. Expression of this gene is highly restricted, with the strongest expression in retina and cochlea. [provided by RefSeq, Jul 2008]
Uniprot Description
MYO3A: a multifunctional protein with an N-terminal kinase domain of the STE20 family and a myosin-head motor domain. Expression of this gene is highly restricted, with the strongest expression in photoreceptors and cochlea. Probably plays a role in vision and hearing. 3 different recessive, loss of function mutations in the encoded protein have been shown to cause nonsyndromic progressive hearing loss.
Protein type: Actin-binding; Kinase, protein; EC 2.7.11.1; Motor; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor); STE group; STE20 family; NinaC subfamily
Chromosomal Location of Human Ortholog: 10p11.1
Cellular Component: filamentous actin; filopodium tip; photoreceptor inner segment; cytoplasm; stereocilium bundle tip; myosin complex; filopodium
Molecular Function: calmodulin binding; actin filament binding; microfilament motor activity; protein serine/threonine kinase activity; plus-end directed microfilament motor activity; actin-dependent ATPase activity; ADP binding; ATP binding; protein kinase activity
Biological Process: positive regulation of filopodium formation; peptidyl-serine phosphorylation; sensory perception of sound; visual perception; protein amino acid autophosphorylation; response to stimulus; peptidyl-threonine phosphorylation; inner ear development
Disease: Deafness, Autosomal Recessive 30
Research Articles on MYO3A
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Product Notes
The Human MYO3A myo3a (Catalog #AAA9715083) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9715083 ELISA Kit recognizes Human MYO3A. It is sometimes possible for the material contained within the vial of "Myosin-IIIa (MYO3A), ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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