Human Muscleblind-like protein 3 (MBNL3) ELISA Kit | MBNL3 elisa kit

Human Muscleblind-like protein 3 (MBNL3) ELISA Kit

Cat. Num. AAA9323979

• Gene Names: MBNL3; CHCR; MBLX; MBXL; MBLX39
• Reactivity: Human
• Synonyms: Muscleblind-like protein 3 (MBNL3); Human Muscleblind-like protein 3 (MBNL3) ELISA Kit; muscleblind-like 3 (Drosophila); RP5-842K24.3; CHCR; FLJ11316; FLJ97142; MBLX; MBLX39; MBXL; Cys3His CCG1-required protein|muscleblind-like 3; MBNL3 elisa kit

• Reactivity: Human
• Specificity: No significant cross-reactivity or interference between this analyte and analogues is observed.

• Samples: Body fluids, tissue homogenates, secretions or feces samples
• Assay Type: Quantitative Sandwich
• Detection Range: 0.625 ng/ml - 20 ng/ml
• Sensitivity: 0.1 ng/ml.
• Intra-assay Precision: Intra-assay CV (%) is less than 15%
• Inter-assay Precision: Inter-assay CV (%) is less than 15%. [CV(%) = SD/mean ×100].
• Preparation and Storage: Store all reagents at 2-8 degree C

Related Product Information for MBNL3 elisa kit

Background/Introduction: This Quantitative Sandwich ELISA kit is only for in vitro research use only! This kit is intended to be used for determination the level of MBNL3 (hereafter termed "analyte") in undiluted original Human body fluids, tissue homogenates, secretions or feces samples. This kit is NOT suitable for assaying non-biological sources of substances.

NCBI and Uniprot Product Information

• NCBI GI #: 282721002
• NCBI GeneID: 55796
• NCBI Accession #: NP_001164172.1
• NCBI GenBank Nucleotide #: NM_001170701.1
• UniProt Accession #: Q9NUK0; Q5JXN8; Q5JXN9; Q5JXP4; Q6UDQ1; Q8IUR4; Q8TAD9; Q8TAF4; Q9H0Z7; Q9UF37
• Molecular Weight: 38,532 Da
• NCBI Official Full Name: muscleblind-like protein 3 isoform 3
• NCBI Official Synonym Full Names: muscleblind-like splicing regulator 3
• NCBI Official Symbol: MBNL3
• NCBI Official Synonym Symbols: CHCR; MBLX; MBXL; MBLX39
• NCBI Protein Information: muscleblind-like protein 3; muscleblind-like 3; Cys3His CCG1-required protein; muscleblind-like X-linked protein
• UniProt Protein Name: Muscleblind-like protein 3
• Protein Family: Muscleblind-like protein
• UniProt Gene Name: MBNL3
• UniProt Synonym Gene Names: CHCR; MBLX39; MBXL
• UniProt Entry Name: MBNL3_HUMAN

NCBI Description

This gene encodes a member of the muscleblind-like family of proteins. The encoded protein may function in regulation of alternative splicing and may play a role in the pathophysiology of myotonic dystrophy. Alternatively spliced transcript variants have been described. [provided by RefSeq, Dec 2009]

Uniprot Description

MBNL3: Mediates pre-mRNA alternative splicing regulation. Acts either as activator or repressor of splicing on specific pre-mRNA targets. Inhibits cardiac troponin-T (TNNT2) pre-mRNA exon inclusion but induces insulin receptor (IR) pre-mRNA exon inclusion in muscle. Antagonizes the alternative splicing activity pattern of CELF proteins. May play a role in myotonic dystrophy pathophysiology (DM). Could inhibit terminal muscle differentiation, acting at approximately the time of myogenin induction. Belongs to the muscleblind family. 5 isoforms of the human protein are produced by alternative splicing.

Protein type: RNA-binding

Chromosomal Location of Human Ortholog: Xq26.2

Cellular Component: cytoplasm; nucleus

Molecular Function: metal ion binding

Biological Process: regulation of RNA splicing; RNA splicing; multicellular organismal development; negative regulation of myoblast differentiation; mRNA processing