Human Muscle Skeletal Receptor Tyrosine Kinase Antibody (MUSK Ab) ELISA Kit | MUSK elisa kit

Human Muscle Skeletal Receptor Tyrosine Kinase Antibody, MUSK Ab ELISA Kit

Cat. Num. AAA705762

• Reactivity: Human
• Synonyms: Muscle Skeletal Receptor Tyrosine Kinase Antibody (MUSK Ab); Human Muscle Skeletal Receptor Tyrosine Kinase Antibody; MUSK Ab ELISA Kit; Human Muscle Skeletal Receptor Tyrosine Kinase Antibody (MUSK Ab) ELISA Kit; MUSK elisa kit

• Reactivity: Human
• Specificity: This assay has high sensitivity and excellent specificity for detection of human MUSK antibody. No significant cross-reactivity or interference between human MUSK antibody and analogues was observed.
• Sequence Length: 947

• Samples: Serum
• Intra-assay Precision: Intra-assay Precision (Precision within an assay): CV%<15%. Three samples of known concentration were tested twenty times on one plate to assess.
• Inter-assay Precision: Inter-assay Precision (Precision between assays): CV%<15%. Three samples of known concentration were tested in twenty assays to assess.
• Preparation and Storage: Unopened test kits should be stored at 2 to 8 degree C upon receipt. Please refer to pdf manual for further storage instructions.

Typical Testing Data/Standard Curve (for reference only)

Related Product Information for MUSK elisa kit

Principle of the Assay: This assay employs the qualitative enzyme immunoassay technique. The microtiter plate provided in this kit has been pre-coated with antigen. Samples are pipetted into the wells with anti-human immunoglobulin conjugated Horseradish Peroxidase (HRP). Any antibodies specific for the antigen present will bind to the pre-coated antigen. Following a wash to remove any unbound reagent, a substrate solution is added to the wells and color develops in proportion to the amount of human MUSK antibody bound in the initial step. The color development is stopped and the intensity of the color is measured.

NCBI and Uniprot Product Information

• NCBI GI #: 45383894
• NCBI GeneID: 373897
• NCBI Accession #: NP_989439.1
• NCBI GenBank Nucleotide #: NM_204108.1
• UniProt Accession #: Q8AXY6
• Molecular Weight: 105,589 Da
• NCBI Official Full Name: muscle, skeletal receptor tyrosine protein kinase
• NCBI Official Synonym Full Names: muscle, skeletal, receptor tyrosine kinase
• NCBI Official Symbol: MUSK
• NCBI Protein Information: muscle, skeletal receptor tyrosine protein kinase; muscle-specific kinase receptor; muscle-specific tyrosine protein kinase receptor
• UniProt Protein Name: Muscle, skeletal receptor tyrosine protein kinase
• Protein Family: Muscle, skeletal receptor tyrosine protein kinase
• UniProt Gene Name: MUSK
• UniProt Synonym Gene Names: MuSK; Muscle-specific kinase receptor
• UniProt Entry Name: MUSK_CHICK

Uniprot Description

Function: Receptor tyrosine kinase which plays a central role in the formation and the maintenance of the neuromuscular junction (NMJ), the synapse between the motor neuron and the skeletal muscle. Recruitment of AGRIN by LRP4 to the MUSK signaling complex induces phosphorylation and activation of MUSK, the kinase of the complex. The activation of MUSK in myotubes regulates the formation of NMJs through the regulation of different processes including the specific expression of genes in subsynaptic nuclei, the reorganization of the actin cytoskeleton and the clustering of the acetylcholine receptors (AChR) in the postsynaptic membrane. May also play a role within the central nervous system by mediating cholinergic responses, synaptic plasticity and memory formation 1 PublicationManual assertion based on experiment in:Ref.1

Catalytic activity: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.