Typical Testing Data/Standard Curve (for reference only)
(Fig.1. Human Melanocortin-2 receptor accessory protein (MRAP) Standard Curve.)
Human Melanocortin-2 Receptor Accessory Protein (MRAP) ELISA Kit | MRAP elisa kit
Human Melanocortin-2 Receptor Accessory Protein (MRAP) ELISA Kit
* Allow all reagents to warm to room temperature for at least 30 minutes before opening.
* Pre-rinse the pipet tip with reagent, use fresh pipet tips for each sample, standard and reagent to avoid contamination.
* Unused wells must be kept desiccated at 4 degree C in the sealed bag provided.
* Mix Thoroughly is very important for the result. It is recommended using low frequency oscillator or slight hand shaking every 10 minutes.
* It is recommended that all samples and standards be assayed in duplicate or triplicate.
Typical Testing Data/Standard Curve (for reference only)
(Fig.1. Human Melanocortin-2 receptor accessory protein (MRAP) Standard Curve.)
Typical Testing Data/Standard Curve (for reference only)
(Fig.1. Human Melanocortin-2 receptor accessory protein (MRAP) Standard Curve.)
Background: MRAP encodes a melanocortin receptor-interacting protein. Melanocortin-2 receptor accessory protein regulates trafficking and function of the melanocortin 2 receptor in the adrenal gland. Melanocortin-2 receptor accessory protein can also modulate signaling of other melanocortin receptors. Mutations in MRAP have been associated with familial glucocorticoid deficiency type 2. Alternatively spliced transcript variants have been described.
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a melanocortin receptor-interacting protein. The encoded protein regulates trafficking and function of the melanocortin 2 receptor in the adrenal gland. The encoded protein can also modulate signaling of other melanocortin receptors. Mutations in this gene have been associated with familial glucocorticoid deficiency type 2. Alternatively spliced transcript variants have been described. [provided by RefSeq, Dec 2009]
Uniprot Description
MRAP: Required for MC2R expression in certain cell types, suggesting that it is involved in the processing, trafficking or function of MC2R. May be involved in the intracellular trafficking pathways in adipocyte cells. Defects in MRAP are the cause of glucocorticoid deficiency type 2 (GCCD2); also known as familial glucocorticoid deficiency type 2 (FGD2). GCCD2 is an autosomal recessive disorder due to congenital insensitivity or resistance to adrenocorticotropin (ACTH). It is characterized by progressive primary adrenal insufficiency, without mineralocorticoid deficiency. 4 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, integral
Chromosomal Location of Human Ortholog: 21q22.1
Cellular Component: endoplasmic reticulum membrane; endoplasmic reticulum; plasma membrane; integral to membrane
Molecular Function: type 5 melanocortin receptor binding; type 3 melanocortin receptor binding; protein binding; type 4 melanocortin receptor binding; adrenocorticotropin hormone receptor binding
Biological Process: positive regulation of cAMP biosynthetic process; brown fat cell differentiation
Disease: Glucocorticoid Deficiency 2
Research Articles on MRAP
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Product Notes
The Human MRAP mrap (Catalog #AAA9715209) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9715209 ELISA Kit recognizes Human MRAP. It is sometimes possible for the material contained within the vial of "Melanocortin-2 Receptor Accessory Protein (MRAP), ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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