Human Mediator of RNA polymerase II transcription subunit 13 like (MED13L) ELISA Kit | MED13L elisa kit
Human Mediator of RNA polymerase II transcription subunit 13 like (MED13L) ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene is a subunit of the Mediator complex, a large complex of proteins that functions as a transcriptional coactivator for most RNA polymerase II-transcribed genes. The encoded protein is involved in early development of the heart and brain. Defects in this gene are a cause of transposition of the great arteries, dextro-looped (DTGA).[provided by RefSeq, Jul 2010]
Uniprot Description
THRAP2: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. This subunit may specifically regulate transcription of targets of the Wnt signaling pathway and SHH signaling pathway. Defects in MED13L are a cause of transposition of the great arteries dextro-looped type 1 (DTGA1). A congenital heart defect consisting of complete inversion of the great vessels, so that the aorta incorrectly arises from the right ventricle and the pulmonary artery incorrectly arises from the left ventricle. This creates completely separate pulmonary and systemic circulatory systems, an arrangement that is incompatible with life. Patients often have atrial and/or ventricular septal defects or other types of shunting that allow some mixing between the circulations in order to support life minimally, but surgical intervention is always required. A chromosomal aberration involving MED13L is found in a patient with transposition of the great arteries, dextro- looped and mental retardation. Translocation t(12;17)(q24.1;q21). Belongs to the Mediator complex subunit 13 family.
Protein type: Adaptor/scaffold
Chromosomal Location of Human Ortholog: 12q24.21
Cellular Component: Srb-mediator complex
Biological Process: transcription from RNA polymerase II promoter; regulation of transcription from RNA polymerase II promoter
Disease: Transposition Of The Great Arteries, Dextro-looped 1
Research Articles on MED13L
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Product Notes
The Human MED13L med13l (Catalog #AAA7239882) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA7239882 ELISA Kit recognizes Human MED13L. It is sometimes possible for the material contained within the vial of "Mediator of RNA polymerase II transcription subunit 13 like (MED13L), ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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