Human MCP-2 ELISA Kit | MCP-2 elisa kit

MCP-2 (Human) OmniKine ELISA Kit

Cat. Num. AAA9502107

• Gene Names: CCL8; HC14; MCP2; MCP-2; SCYA8; SCYA10
• Reactivity: Human
• Synonyms: MCP-2; MCP-2 (Human) OmniKine ELISA Kit; C-C Motif Chemokine Ligand 8; Small Inducible Cytokine Subfamily A (Cys-Cys); Member 8 (Monocyte Chemotactic Protein 2); Monocyte Chemoattractant Protein; Chemokine (C-C Motif) Ligand 8; Monocyte Chemotactic Protein; Small-Inducible Cytokine A8; SCYA10; SCYA8; HC14; MCP2; C-C Motif Chemokine; MCP-2 elisa kit

• Reactivity: Human
• Specificity: The OmniKine Human MCP-2 ELISA is capable of recognizing both recombinant and naturally produced Human MCP-2 proteins. The antigens listed below were tested at 50ng/ml the following antigens did not exhibit significant cross reactivity; Human CXCL16, GRO-alpha/MGSA, GRO-beta, GRO-gamma, HCC-1, IL-8, MCP-1, MCP-3, MCP-4, MIP-1alpha, MIP-1beta, RANTES; Murine JE/MCP-1, MCP-2, MCP-3, MCP-5, MIP-1alpha, MIP-1beta; Rat MCP-1
• Form/Format: 12 x 8-Well Microstrips
• Sequence Length: 99

• Assay Type: Sandwich ELISA
• Detection Range: 8-500 pg/ml
• Detection Method: Colorimetric 450 nm
• Subtype: None
• Preparation and Storage: Store at 4 degree C for 6 months.

NCBI and Uniprot Product Information

• NCBI GI #: 22538816
• NCBI GeneID: 6355
• NCBI Accession #: NP_005614.2
• NCBI GenBank Nucleotide #: NM_005623.2
• UniProt Accession #: P80075; P78388; A0AV77
• Molecular Weight: 11,246 Da
• NCBI Official Full Name: C-C motif chemokine 8
• NCBI Official Synonym Full Names: C-C motif chemokine ligand 8
• NCBI Official Symbol: CCL8
• NCBI Official Synonym Symbols: HC14; MCP2; MCP-2; SCYA8; SCYA10
• NCBI Protein Information: C-C motif chemokine 8
• UniProt Protein Name: C-C motif chemokine 8
• UniProt Gene Name: CCL8
• UniProt Synonym Gene Names: MCP2; SCYA10; SCYA8; MCP-2

NCBI Description

This antimicrobial gene is one of several chemokine genes clustered on the q-arm of chromosome 17. Chemokines form a superfamily of secreted proteins involved in immunoregulatory and inflammatory processes. The superfamily is divided into four subfamilies based on the arrangement of N-terminal cysteine residues of the mature peptide. This chemokine is a member of the CC subfamily which is characterized by two adjacent cysteine residues. This cytokine displays chemotactic activity for monocytes, lymphocytes, basophils and eosinophils. By recruiting leukocytes to sites of inflammation this cytokine may contribute to tumor-associated leukocyte infiltration and to the antiviral state against HIV infection. [provided by RefSeq, Sep 2014]

Uniprot Description

CCL8: Chemotactic factor that attracts monocytes, lymphocytes, basophils and eosinophils. May play a role in neoplasia and inflammatory host responses. This protein can bind heparin. The processed form MCP-2(6-76) does not show monocyte chemotactic activity, but inhibits the chemotactic effect most predominantly of CCL7, and also of CCL2 and CCL5 and CCL8. Belongs to the intercrine beta (chemokine CC) family.

Protein type: Chemokine; Motility/polarity/chemotaxis; Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 17q12

Cellular Component: cell; extracellular space

Molecular Function: CCR chemokine receptor binding; chemokine activity; heparin binding; phospholipase activator activity; protein kinase activity

Biological Process: calcium ion transport; cell-cell signaling; cellular calcium ion homeostasis; chemotaxis; exocytosis; G-protein coupled receptor signaling pathway; inflammatory response; lymphocyte chemotaxis; monocyte chemotaxis; neutrophil chemotaxis; positive regulation of GTPase activity; positive regulation of leukocyte migration; protein amino acid phosphorylation; response to virus; signal transduction