Human Lysyl Oxidase (LOX) ELISA Kit | LOX elisa kit

Human Lysyl Oxidase (LOX) ELISA Kit

Cat. Num. AAA453322

• Gene Names: LOX; AAT10
• Reactivity: Human
• Synonyms: Lysyl Oxidase (LOX); Human Lysyl Oxidase (LOX) ELISA Kit; Protein-Lysine 6-Oxidase; LOX elisa kit

• Reactivity: Human
• Sequence Length: 417

• Samples: Serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids.
• Assay Type: Sandwich
• Detection Range: 0.781-50ng/mL
• Sensitivity: 0.33ng/mL
• Intra Assay: CV<10%
• Inter Assay: CV<12%
• Preparation and Storage: For unopened kit, all reagents should be kept according to the labels on vials. The TMB Substrate, Wash Buffer, Stop Solution should be stored at 4 degree C. All others should be stored at -20 degree C.

Typical Standard Curve/Testing Data

NCBI and Uniprot Product Information

• NCBI GI #: 20149540
• NCBI GeneID: 4015
• NCBI Accession #: NP_002308.2
• NCBI GenBank Nucleotide #: NM_002317.6
• UniProt Accession #: P28300; Q5FWF0; B2R5Q3
• Molecular Weight: 46,944 Da
• NCBI Official Full Name: protein-lysine 6-oxidase isoform 1 preproprotein
• NCBI Official Synonym Full Names: lysyl oxidase
• NCBI Official Symbol: LOX
• NCBI Official Synonym Symbols: AAT10
• NCBI Protein Information: protein-lysine 6-oxidase
• UniProt Protein Name: Protein-lysine 6-oxidase
• Protein Family: Linoleate 9/13-lipoxygenase
• UniProt Gene Name: LOX

NCBI Description

This gene encodes a member of the lysyl oxidase family of proteins. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate a regulatory propeptide and the mature enzyme. The copper-dependent amine oxidase activity of this enzyme functions in the crosslinking of collagens and elastin, while the propeptide may play a role in tumor suppression. In addition, defects in this gene have been linked with predisposition to thoracic aortic aneurysms and dissections. [provided by RefSeq, Jul 2016]

Uniprot Description

Responsible for the post-translational oxidative deamination of peptidyl lysine residues in precursors to fibrous collagen and elastin. In addition to cross-linking of extracellular matrix proteins, may have a direct role in tumor suppression.