Human Keratin 5 ELISA Kit | KRT5 elisa kit

Human Keratin 5 ELISA Kit

Cat. Num. AAA3804883

• Gene Names: KRT5; K5; CK5; DDD; DDD1; EBS2; KRT5A
• Reactivity: Human
• Synonyms: Keratin 5; Human Keratin 5 ELISA Kit; KRT5 elisa kit

• Reactivity: Human
• Sequence Length: 590

• Samples: Serum, plasma, cell culture supernate and other biological fluids
• Assay Type: Sandwich
• Detection Range: 250 pg/ml-4000 pg/ml
• Sensitivity: 10 pg/ml

Typical Testing Data/Standard Curve (for reference only)

Related Product Information for KRT5 elisa kit

Intended Use: The Stop Solution changes the color from blue to yellow and the intensity of the color is measured at 450 nm using a spectrophotometer. In order to measure the concentration ofKERATIN 5in the sample, This KERATIN 5ELISA Kit includes a set of calibration standards. The calibration standards are assayed at the same time as the samples and allow the operator to produce a standard curve of Optical Density versusKERATIN 5concentration. The concentration ofKERATIN 5in the samples is then determined by comparing the O.D. of the samples to the standard curve.

NCBI and Uniprot Product Information

• NCBI GI #: 119395754
• NCBI GeneID: 3852
• NCBI Accession #: NP_000415.2
• NCBI GenBank Nucleotide #: NP_000415.2
• UniProt Accession #: P13647
• NCBI Official Full Name: keratin, type II cytoskeletal 5
• NCBI Official Synonym Full Names: keratin 5
• NCBI Official Symbol: KRT5
• NCBI Official Synonym Symbols: K5; CK5; DDD; DDD1; EBS2; KRT5A
• NCBI Protein Information: keratin, type II cytoskeletal 5
• UniProt Protein Name: Keratin, type II cytoskeletal 5
• Protein Family: Keratin
• UniProt Gene Name: KRT5
• UniProt Synonym Gene Names: CK-5; K5
• UniProt Entry Name: K2C5_HUMAN

NCBI Description

The protein encoded by this gene is a member of the keratin gene family. The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. This type II cytokeratin is specifically expressed in the basal layer of the epidermis with family member KRT14. Mutations in these genes have been associated with a complex of diseases termed epidermolysis bullosa simplex. The type II cytokeratins are clustered in a region of chromosome 12q12-q13. [provided by RefSeq, Jul 2008]

Uniprot Description

K5: Heterotetramer of two type I and two type II keratins. Keratin-5 associates with keratin-14. Interacts with TCHP. Belongs to the intermediate filament family.

Protein type: Cytoskeletal

Chromosomal Location of Human Ortholog: 12q13.13

Cellular Component: membrane; mitochondrion; keratin filament; cytoplasm; plasma membrane; intermediate filament; cytosol; nucleus

Molecular Function: protein binding; structural constituent of cytoskeleton

Biological Process: hemidesmosome assembly; epidermis development

Disease: Epidermolysis Bullosa Simplex, Localized; Epidermolysis Bullosa Simplex, Generalized; Dowling-degos Disease 1; Epidermolysis Bullosa Simplex With Migratory Circinate Erythema; Epidermolysis Bullosa Simplex, Autosomal Recessive 1; Epidermolysis Bullosa Simplex With Mottled Pigmentation; Epidermolysis Bullosa Simplex, Dowling-meara Type