Typical Testing Data/Standard Curve (for reference only)
(Fig.1. Human Interferon alpha/beta receptor 1 (IFNa/bR1) Standard Curve.)
Human Interferon alpha/beta Receptor 1 (IFNa/bR1) ELISA Kit | IFNa/bR1 elisa kit
Human Interferon alpha/beta Receptor 1 (IFNa/bR1) ELISA Kit
* Allow all reagents to warm to room temperature for at least 30 minutes before opening.
* Pre-rinse the pipet tip with reagent, use fresh pipet tips for each sample, standard and reagent to avoid contamination.
* Unused wells must be kept desiccated at 4 degree C in the sealed bag provided.
* Mix Thoroughly is very important for the result. It is recommended using low frequency oscillator or slight hand shaking every 10 minutes.
* It is recommended that all samples and standards be assayed in duplicate or triplicate.
Typical Testing Data/Standard Curve (for reference only)
(Fig.1. Human Interferon alpha/beta receptor 1 (IFNa/bR1) Standard Curve.)
Typical Testing Data/Standard Curve (for reference only)
(Fig.1. Human Interferon alpha/beta receptor 1 (IFNa/bR1) Standard Curve.)
Background: Streuli et al. (1980) showed that at least 3 different IFN-alpha genes are expressed in man. Furthermore, study of genomic DNA revealed the presence of at least 8 IFN genes.Nagata et al. (1980) found that the alpha-interferon genes are devoid of intervening sequences. Using radioactive probes from purified cDNA clones of interferons, Owerbach et al. (1981) located at least 8 leukocyte interferon genes and a fibroblast interferon gene on chromosome 9. Shows et al. (1982) found that the alpha- and beta-interferon genes are on 9p. The mapping to 9pter-q12 was accomplished by blot hybridization of cloned interferon cDNA to DNA from human-mouse cell hybrids with a translocation involving chromosome 9.
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene is a type I membrane protein that forms one of the two chains of a receptor for interferons alpha and beta. Binding and activation of the receptor stimulates Janus protein kinases, which in turn phosphorylate several proteins, including STAT1 and STAT2. The encoded protein also functions as an antiviral factor. [provided by RefSeq, Jul 2008]
Uniprot Description
IFNAR1: receptor for interferons alpha and beta. Belongs to the type II cytokine family of receptors. Binding to type I IFNs triggers tyrosine phosphorylation of a number of proteins including JAKs, TYK2, STAT proteins and IFNR alpha- and beta-subunits themselves. Tyk2 tyrosine kinase is essential for stable cell surface expression of IFNAR1. Present in all tissues and even on the surface of most IFN-resistant cells.
Protein type: Receptor, cytokine; Membrane protein, integral
Chromosomal Location of Human Ortholog: 21q22.11
Cellular Component: integral to plasma membrane; integral to membrane; plasma membrane
Molecular Function: protein binding; interferon receptor activity; interferon-alpha/beta receptor activity
Biological Process: positive regulation of interferon-gamma production; cell surface receptor linked signal transduction; T cell activation; response to virus; cytokine and chemokine mediated signaling pathway; positive regulation of interleukin-1 beta secretion; JAK-STAT cascade; interferon type I biosynthetic process; defense response to virus
Research Articles on IFNa/bR1
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Product Notes
The Human IFNa/bR1 ifnar1 (Catalog #AAA9716213) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9716213 ELISA Kit recognizes Human IFNa/bR1. It is sometimes possible for the material contained within the vial of "Interferon alpha/beta Receptor 1 (IFNa/bR1), ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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