Human IMPDH2 ELISA Kit | IMPDH2 elisa kit

Human IMPDH2 ELISA Kit

Cat. Num. AAA3804153

• Gene Names: IMPDH2; IMPD2; IMPDH-II
• Reactivity: Human
• Synonyms: IMPDH2; Human IMPDH2 ELISA Kit; IMPDH2 elisa kit

• Reactivity: Human
• Sequence Length: 514

• Samples: Serum, plasma, cell culture supernate and other biological fluids
• Assay Type: Sandwich
• Detection Range: 12.5 U/L-200 U/L
• Sensitivity: 1 U/L

Typical Testing Data/Standard Curve (for reference only)

Related Product Information for IMPDH2 elisa kit

Intended Use: The Stop Solution changes the color from blue to yellow and the intensity of the color is measured at 450 nm using a spectrophotometer. In order to measure the concentration ofIMPDH2in the sample, This IMPDH2ELISA Kit includes a set of calibration standards. The calibration standards are assayed at the same time as the samples and allow the operator to produce a standard curve of Optical Density versusIMPDH2concentration. The concentration ofIMPDH2in the samples is then determined by comparing the O.D. of the samples to the standard curve.

NCBI and Uniprot Product Information

• NCBI GI #: 66933016
• NCBI GeneID: 3615
• NCBI Accession #: NP_000875
• NCBI GenBank Nucleotide #: NP_000875.2
• UniProt Accession #: P12268
• NCBI Official Full Name: inosine-5'-monophosphate dehydrogenase 2
• NCBI Official Synonym Full Names: inosine monophosphate dehydrogenase 2
• NCBI Official Symbol: IMPDH2
• NCBI Official Synonym Symbols: IMPD2; IMPDH-II
• NCBI Protein Information: inosine-5'-monophosphate dehydrogenase 2
• UniProt Protein Name: Inosine-5'-monophosphate dehydrogenase 2
• UniProt Gene Name: IMPDH2
• UniProt Entry Name: IMDH2_HUMAN

NCBI Description

This gene encodes the rate-limiting enzyme in the de novo guanine nucleotide biosynthesis. It is thus involved in maintaining cellular guanine deoxy- and ribonucleotide pools needed for DNA and RNA synthesis. The encoded protein catalyzes the NAD-dependent oxidation of inosine-5'-monophosphate into xanthine-5'-monophosphate, which is then converted into guanosine-5'-monophosphate. This gene is up-regulated in some neoplasms, suggesting it may play a role in malignant transformation. [provided by RefSeq, Jul 2008]

Uniprot Description

IMPDH2: a rate limiting enzyme in the de novo synthesis of guanine nucleotides and therefore is involved in the regulation of cell growth. It may also have a role in the development of malignancy and the growth progression of some tumors.

Protein type: Oxidoreductase; EC 1.1.1.205; Xenobiotic Metabolism - drug metabolism - other enzymes; Nucleotide Metabolism - purine

Chromosomal Location of Human Ortholog: 3p21.2

Cellular Component: peroxisomal membrane; membrane; cytoplasm; nucleus; cytosol

Molecular Function: DNA binding; RNA binding; metal ion binding; nucleotide binding; IMP dehydrogenase activity

Biological Process: purine ribonucleoside monophosphate biosynthetic process; lymphocyte proliferation; nucleobase, nucleoside and nucleotide metabolic process; retina development in camera-type eye; GMP biosynthetic process; purine base metabolic process; protein homotetramerization