Human IL-34 ELISA Kit | IL-34 elisa kit

IL-34 (Human) OmniKine ELISA Kit

Cat. Num. AAA9501974

• Gene Names: IL34; IL-34; C16orf77
• Reactivity: Human
• Synonyms: IL-34; IL-34 (Human) OmniKine ELISA Kit; Interleukin-34; C16orf77; IL-34 elisa kit

• Reactivity: Human
• Specificity: The OmniKine Human IL-34 ELISA is capable of recognizing both recombinant and naturally produced Human IL-34 proteins. The antigens listed below were tested at 50 ng/ml and did not exhibit significant cross reactivity or interference.; Murine: IL-34
• Form/Format: 12 x 8-Well Microstrips
• Sequence Length: 241

• Samples: Plasma, serum, lysate
• Assay Type: Sandwich ELISA
• Detection Range: 188-6000 pg/ml
• Sensitivity: 188-6000 pg/ml
• Detection Method: Colorimetric 450 nm
• Subtype: None
• Preparation and Storage: Store at 4 degree C for 6 months.

Testing Data

(The OmniKine Human IL-34 ELISA Kit allows for the detection and quantification of endogenous levels of natural and/or recombinant Human IL-34 proteins within the range of 188-6000 pg/ml.)

NCBI and Uniprot Product Information

• NCBI GI #: 289666750
• NCBI GeneID: 146433
• NCBI Accession #: NP_001166242.1
• NCBI GenBank Nucleotide #: NM_001172771.1
• UniProt Accession #: Q6ZMJ4; Q8N6L2; B2RC28; B2Z4A8; B2ZC70
• Molecular Weight: 27,354 Da
• NCBI Official Full Name: interleukin-34 isoform 2
• NCBI Official Synonym Full Names: interleukin 34
• NCBI Official Symbol: IL34
• NCBI Official Synonym Symbols: IL-34; C16orf77
• NCBI Protein Information: interleukin-34
• UniProt Protein Name: Interleukin-34
• UniProt Gene Name: IL34
• UniProt Synonym Gene Names: C16orf77; IL-34

NCBI Description

Interleukin-34 is a cytokine that promotes the differentiation and viability of monocytes and macrophages through the colony-stimulating factor-1 receptor (CSF1R; MIM 164770) (Lin et al., 2008 [PubMed 18467591]).[supplied by OMIM, May 2008]

Uniprot Description

IL34: Cytokine that promotes the proliferation, survival and differentiation of monocytes and macrophages. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, and in the regulation of bone resorption. Signaling via CSF1R and its downstream effectors stimulates phosphorylation of MAPK1/ERK2 AND MAPK3/ERK1. Belongs to the IL-34 family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Cell cycle regulation; Cytokine; Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 16q22.1

Cellular Component: extracellular region; extracellular space

Molecular Function: cytokine activity; growth factor activity; macrophage colony-stimulating factor receptor binding

Biological Process: inflammatory response; innate immune response; positive regulation of cell proliferation; positive regulation of macrophage differentiation; positive regulation of monocyte differentiation; positive regulation of protein phosphorylation