Human IL-2 ELISA Kit | IL-2 elisa kit

IL-2 (Human) OmniKine ELISA Kit

Cat. Num. AAA9501858

• Gene Names: IL2; IL-2; TCGF; lymphokine
• Reactivity: Human
• Synonyms: IL-2; IL-2 (Human) OmniKine ELISA Kit; Interleukin-2; T-cell growth factor; Aldesleukin; TCGF; IL-2 elisa kit

• Reactivity: Human
• Specificity: The OmniKine Human IL-2 ELISA is capable of recognizing both recombinant and naturally produced Human IL-2 proteins. The antigens listed below were tested at 50 ng/ml and did not exhibit significant cross reactivity or interference.; Human: G-CSF, GM-CSF, IL-1alpha, IL-1beta, sIL-2R, IL-3, IL-4, IL-6, IL-7, IL-8, TNF-alpha; Murine: IL-2; Rat: IL-2
• Form/Format: 12 x 8-Well Microstrips
• Sequence Length: 153

• Samples: Plasma, serum, lysate
• Assay Type: Sandwich ELISA
• Detection Range: 63-4000 pg/ml
• Sensitivity: 63-4000 pg/ml
• Detection Method: Colorimetric 450 nm
• Subtype: None
• Preparation and Storage: Store at 4 degree C for 6 months.

Testing Data

(The OmniKine Human IL-2 ELISA Kit allows for the detection and quantification of endogenous levels of natural and/or recombinant Human IL-2 proteins within the range of 63-4000 pg/ml.)

NCBI and Uniprot Product Information

• NCBI GI #: 28178861
• NCBI GeneID: 3558
• NCBI Accession #: NP_000577.2
• NCBI GenBank Nucleotide #: NM_000586.3
• UniProt Accession #: P60568; P01585
• Molecular Weight: 17,628 Da
• NCBI Official Full Name: interleukin-2
• NCBI Official Synonym Full Names: interleukin 2
• NCBI Official Symbol: IL2
• NCBI Official Synonym Symbols: IL-2; TCGF; lymphokine
• NCBI Protein Information: interleukin-2
• UniProt Protein Name: Interleukin-2
• UniProt Gene Name: IL2
• UniProt Synonym Gene Names: IL-2; TCGF

NCBI Description

The protein encoded by this gene is a secreted cytokine that is important for the proliferation of T and B lymphocytes. The receptor of this cytokine is a heterotrimeric protein complex whose gamma chain is also shared by interleukin 4 (IL4) and interleukin 7 (IL7). The expression of this gene in mature thymocytes is monoallelic, which represents an unusual regulatory mode for controlling the precise expression of a single gene. The targeted disruption of a similar gene in mice leads to ulcerative colitis-like disease, which suggests an essential role of this gene in the immune response to antigenic stimuli. [provided by RefSeq, Jul 2008]

Uniprot Description

IL2: Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine- activated killer cells, natural killer cells, and glioma cells. A chromosomal aberration involving IL2 is found in a form of T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(4;16)(q26;p13) with involves TNFRSF17. Belongs to the IL-2 family.

Protein type: Cytokine; Oncoprotein; Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 4q27

Cellular Component: extracellular region; extracellular space; intracellular

Molecular Function: carbohydrate binding; cytokine activity; glycosphingolipid binding; growth factor activity; interleukin-2 receptor binding; kappa-type opioid receptor binding; kinase activator activity; Ras guanyl-nucleotide exchange factor activity

Biological Process: adaptive immune response; cell adhesion; cell-cell signaling; elevation of cytosolic calcium ion concentration; immune response; leukocyte activation involved in immune response; MAPK cascade; natural killer cell activation; negative regulation of apoptosis; negative regulation of B cell apoptotic process; negative regulation of heart contraction; negative regulation of inflammatory response; negative regulation of lymphocyte proliferation; negative regulation of protein phosphorylation; positive regulation of activated T cell proliferation; positive regulation of B cell proliferation; positive regulation of cell growth; positive regulation of cell proliferation; positive regulation of GTPase activity; positive regulation of immunoglobulin secretion; positive regulation of inflammatory response; positive regulation of interferon-gamma production; positive regulation of interleukin-17 production; positive regulation of isotype switching to IgG isotypes; positive regulation of regulatory T cell differentiation; positive regulation of tissue remodeling; positive regulation of transcription from RNA polymerase II promoter; positive regulation of tyrosine phosphorylation of STAT protein; protein kinase C-activating G-protein coupled receptor signaling pathway; regulation of regulatory T cell differentiation; regulation of T cell homeostatic proliferation; response to ethanol; T cell differentiation