Human IFN-gamma ELISA Kit | IFN-gamma elisa kit

IFN-gamma (Human) OmniKine ELISA Kit

Cat. Num. AAA9501849

• Gene Names: IFNG; IFG; IFI
• Reactivity: Human
• Synonyms: IFN-gamma; IFN-gamma (Human) OmniKine ELISA Kit; Interferon gamma; Immune interferon; IFN-gamma elisa kit

• Reactivity: Human
• Specificity: The OmniKine Human IFN-gamma ELISA is capable of recognizing both recombinant and naturally produced Human IFN-gamma proteins. The antigens listed below were tested at 50 ng/ml and did not exhibit significant cross reactivity or interference.; Human: IFN-lambda1, IFN-lambda2, IFN-beta, IL-10, IL-12, IL-16, IL-17A, IL-17B, IL-17D, IL-17E, IL-17F; Murine: IFN-lambda2, IFN-gamma, IL-10, IL-12; Rat: IFN-gamma, IL-10
• Form/Format: 12 x 8-Well Microstrips
• Sequence Length: 166

• Samples: Plasma, serum, lysate
• Assay Type: Sandwich ELISA
• Detection Range: 46-3000 pg/ml
• Sensitivity: 46-3000 pg/ml
• Detection Method: Colorimetric 450 nm
• Subtype: None
• Preparation and Storage: Store at 4 degree C for 6 months.

Testing Data

(The OmniKine Human IFN-gamma ELISA Kit allows for the detection and quantification of endogenous levels of natural and/or recombinant Human IFN-gamma proteins within the range of 46-3000 pg/ml.)

NCBI and Uniprot Product Information

• NCBI GI #: 56786138
• NCBI GeneID: 3458
• NCBI Accession #: NP_000610.2
• NCBI GenBank Nucleotide #: NM_000619.2
• UniProt Accession #: P01579; Q53ZV4; B5BU88
• Molecular Weight: 19,348 Da
• NCBI Official Full Name: interferon gamma
• NCBI Official Synonym Full Names: interferon gamma
• NCBI Official Symbol: IFNG
• NCBI Official Synonym Symbols: IFG; IFI
• NCBI Protein Information: interferon gamma
• UniProt Protein Name: Interferon gamma
• UniProt Gene Name: IFNG
• UniProt Synonym Gene Names: IFN-gamma

NCBI Description

This gene encodes a soluble cytokine that is a member of the type II interferon class. The encoded protein is secreted by cells of both the innate and adaptive immune systems. The active protein is a homodimer that binds to the interferon gamma receptor which triggers a cellular response to viral and microbial infections. Mutations in this gene are associated with an increased susceptibility to viral, bacterial and parasitic infections and to several autoimmune diseases. [provided by RefSeq, Dec 2015]

Uniprot Description

IFNG: Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. Homodimer. Released primarily from activated T lymphocytes. Belongs to the type II (or gamma) interferon family.

Protein type: Cytokine; Membrane protein, integral; Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 12q15

Cellular Component: extracellular region; extracellular space; intracellular

Molecular Function: cytokine activity; interferon-gamma receptor binding; protein binding

Biological Process: adaptive immune response; apoptosis; cell cycle arrest; cell motility; cell surface receptor signaling pathway; defense response to virus; humoral immune response; negative regulation of epithelial cell differentiation; negative regulation of gene expression; negative regulation of interleukin-17 production; negative regulation of smooth muscle cell proliferation; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; positive regulation of autophagy; positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation during immune response; positive regulation of cell proliferation; positive regulation of core promoter binding; positive regulation of epithelial cell migration; positive regulation of gene expression; positive regulation of interleukin-12 production; positive regulation of interleukin-23 production; positive regulation of killing of cells of another organism; positive regulation of membrane protein ectodomain proteolysis; positive regulation of nitric oxide biosynthetic process; positive regulation of osteoclast differentiation; positive regulation of peptidyl-serine phosphorylation of STAT protein; positive regulation of protein complex assembly; positive regulation of protein deacetylation; positive regulation of protein import into nucleus, translocation; positive regulation of protein phosphorylation; positive regulation of protein serine/threonine kinase activity; positive regulation of smooth muscle cell apoptotic process; positive regulation of tumor necrosis factor (ligand) superfamily member 11 production; positive regulation of tyrosine phosphorylation of STAT protein; protein import into nucleus, translocation; regulation of growth; regulation of insulin secretion; regulation of protein ADP-ribosylation; regulation of receptor activity; regulation of regulatory T cell differentiation; response to virus

Disease: Aplastic Anemia; Hepatitis C Virus, Susceptibility To; Human Immunodeficiency Virus Type 1, Susceptibility To; Mycobacterium Tuberculosis, Susceptibility To; Tuberous Sclerosis 2