Typical Testing Data/Standard Curve (for reference only)
(Fig.1. Human Homeobox protein Meis1 (MEIS1) Standard Curve.)
Human Homeobox Protein Meis1 (MEIS1) ELISA Kit | MEIS1 elisa kit
Human Homeobox Protein Meis1 (MEIS1) ELISA Kit
* Allow all reagents to warm to room temperature for at least 30 minutes before opening.
* Pre-rinse the pipet tip with reagent, use fresh pipet tips for each sample, standard and reagent to avoid contamination.
* Unused wells must be kept desiccated at 4 degree C in the sealed bag provided.
* Mix Thoroughly is very important for the result. It is recommended using low frequency oscillator or slight hand shaking every 10 minutes.
* It is recommended that all samples and standards be assayed in duplicate or triplicate.
Typical Testing Data/Standard Curve (for reference only)
(Fig.1. Human Homeobox protein Meis1 (MEIS1) Standard Curve.)
Typical Testing Data/Standard Curve (for reference only)
(Fig.1. Human Homeobox protein Meis1 (MEIS1) Standard Curve.)
Background: Homeobox genes, of which the most well-characterized category is represented by the HOX genes, play a crucial role in normal development. In addition, several homeoproteins are involved in neoplasia. MEIS1 encodes a homeobox protein belonging to the TALE ('three amino acid loop extension') family of homeodomain-containing proteins.
NCBI and Uniprot Product Information
NCBI Description
Homeobox genes, of which the most well-characterized category is represented by the HOX genes, play a crucial role in normal development. In addition, several homeoproteins are involved in neoplasia. This gene encodes a homeobox protein belonging to the TALE ('three amino acid loop extension') family of homeodomain-containing proteins. [provided by RefSeq, Jul 2008]
Uniprot Description
MEIS1: Acts as a transcriptional regulator of PAX6. Acts as a transcriptional activator of PF4 in complex with PBX1 or PBX2. Required for hematopoiesis, megakaryocyte lineage development and vascular patterning. May function as a cofactor for HOXA7 and HOXA9 in the induction of myeloid leukemias. Defects in MEIS1 could be a cause of susceptibility to restless legs syndrome type 7 (RLS7). Restless legs syndrome (RLS) is a neurologic sleep/wake disorder characterized by uncomfortable and unpleasant sensations in the legs that appear at rest, usually at night, inducing an irresistible desire to move the legs. The disorder results in nocturnal insomnia and chronic sleep deprivation. Belongs to the TALE/MEIS homeobox family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: DNA-binding
Chromosomal Location of Human Ortholog: 2p14
Cellular Component: nucleus; transcription factor complex
Molecular Function: chromatin binding; protein binding; protein heterodimerization activity; RNA polymerase II transcription factor activity, enhancer binding
Biological Process: angiogenesis; lens morphogenesis in camera-type eye; locomotory behavior; negative regulation of myeloid cell differentiation; negative regulation of neuron differentiation; positive regulation of transcription from RNA polymerase II promoter; transcription from RNA polymerase II promoter
Disease: Restless Legs Syndrome, Susceptibility To, 7
Research Articles on MEIS1
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Product Notes
The Human MEIS1 meis1 (Catalog #AAA9715326) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9715326 ELISA Kit recognizes Human MEIS1. It is sometimes possible for the material contained within the vial of "Homeobox Protein Meis1 (MEIS1), ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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