Human GRO/MGSA ELISA Kit | GRO/MGSA elisa kit

GRO/MGSA (Human) OmniKine ELISA Kit

Cat. Num. AAA9501846

• Gene Names: CXCL1; FSP; GRO1; GROa; MGSA; NAP-3; SCYB1; MGSA-a
• Reactivity: Human
• Synonyms: GRO/MGSA; GRO/MGSA (Human) OmniKine ELISA Kit; Growth-regulated alpha protein; C-X-C motif chemokine 1; GRO-alpha(1-73); Melanoma growth stimulatory activity; Neutrophil-activating protein 3; NAP-3; GROA; GRO1; SCYB1; GRO/MGSA elisa kit

• Reactivity: Human
• Specificity: The OmniKine Human GROalpha/MGSA ELISA is capable of recognizing both recombinant and naturally produced Human GROalpha/MGSA proteins. The antigens listed below were tested at 50 ng/ml and exhibited less than 1% cross reactivity.; Human: GRObeta, GROgamma; The antigens listed below were tested at 50 ng/ml and did not exhibit significant cross reactivity or interference.; Human: BCA-1, ENA-78, GCP-2, I-TAC, IL-8, IP-10, MIG, NAP-2, PF-4, SDF-1alpha, SDF-1beta; Murine: KC, MIP-2; Rat: GROalpha, GRObeta
• Form/Format: 12 x 8-Well Microstrips
• Sequence Length: 107

• Samples: Plasma, serum, lysate
• Assay Type: Sandwich ELISA
• Detection Range: 16-1000 pg/ml
• Sensitivity: 16-1000 pg/ml
• Detection Method: Colorimetric 450 nm
• Subtype: None
• Preparation and Storage: Store at 4 degree C for 6 months.

Testing Data

(The OmniKine Human GRO/MGSA ELISA Kit allows for the detection and quantification of endogenous levels of natural and/or recombinant Human GRO/MGSA proteins within the range of 16-1000 pg/ml.)

NCBI and Uniprot Product Information

• NCBI GI #: 4504153
• NCBI GeneID: 2919
• NCBI Accession #: NP_001502.1
• NCBI GenBank Nucleotide #: NM_001511.3
• UniProt Accession #: P09341; Q9UCR7
• Molecular Weight: 11,301 Da
• NCBI Official Full Name: growth-regulated alpha protein
• NCBI Official Synonym Full Names: C-X-C motif chemokine ligand 1
• NCBI Official Symbol: CXCL1
• NCBI Official Synonym Symbols: FSP; GRO1; GROa; MGSA; NAP-3; SCYB1; MGSA-a
• NCBI Protein Information: growth-regulated alpha protein
• UniProt Protein Name: Growth-regulated alpha protein
• UniProt Gene Name: CXCL1
• UniProt Synonym Gene Names: GRO; GRO1; GROA; MGSA; SCYB1; MGSA; NAP-3

NCBI Description

This antimicrobial gene encodes a member of the CXC subfamily of chemokines. The encoded protein is a secreted growth factor that signals through the G-protein coupled receptor, CXC receptor 2. This protein plays a role in inflammation and as a chemoattractant for neutrophils. Aberrant expression of this protein is associated with the growth and progression of certain tumors. A naturally occurring processed form of this protein has increased chemotactic activity. Alternate splicing results in coding and non-coding variants of this gene. A pseudogene of this gene is found on chromosome 4. [provided by RefSeq, Sep 2014]

Uniprot Description

CXCL1: Has chemotactic activity for neutrophils. May play a role in inflammation and exerts its effects on endothelial cells in an autocrine fashion. In vitro, the processed forms GRO- alpha(4-73), GRO-alpha(5-73) and GRO-alpha(6-73) show a 30-fold higher chemotactic activity. Belongs to the intercrine alpha (chemokine CxC) family.

Protein type: Motility/polarity/chemotaxis; Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 4q13.3

Cellular Component: extracellular region; extracellular space

Molecular Function: chemokine activity; CXCR chemokine receptor binding; enzyme activator activity; growth factor activity; receptor binding

Biological Process: actin cytoskeleton organization; cell proliferation; chemotaxis; G-protein coupled receptor signaling pathway; immune response; inflammatory response; negative regulation of cell proliferation; nervous system development; neutrophil degranulation; positive regulation of catalytic activity; response to lipopolysaccharide; signal transduction