Human F box/WD repeat containing protein 4 (FBXW4) ELISA Kit | FBXW4 elisa kit

Human F box/WD repeat containing protein 4 (FBXW4) ELISA Kit

Cat. Num. AAA7213355

• Gene Names: FBXW4; DAC; FBW4; FBWD4; SHFM3; SHSF3
• Reactivity: Human
• Synonyms: F box/WD repeat containing protein 4 (FBXW4); Human F box/WD repeat containing protein 4 (FBXW4) ELISA Kit; FBXW4 elisa kit

• Reactivity: Human

• Samples: Serum, plasma, Cell Culture Supernatants, body fluid and tissue homogenate
• Assay Type: Competitive
• Detection Range: 250-5000pg/mL
• Sensitivity: 1.0pg/mL
• Preparation and Storage: Store all reagents at 2-8 degree C.

Product Categories/Family for FBXW4 elisa kit

Epigenetics and Nuclear Signaling

NCBI and Uniprot Product Information

• NCBI GI #: 11545739
• NCBI GeneID: 6468
• NCBI Accession #: NP_071322.1
• NCBI GenBank Nucleotide #: NM_022039.3
• Molecular Weight: 46,337 Da
• NCBI Official Full Name: F-box/WD repeat-containing protein 4
• NCBI Official Synonym Full Names: F-box and WD repeat domain containing 4
• NCBI Official Symbol: FBXW4
• NCBI Official Synonym Symbols: DAC; FBW4; FBWD4; SHFM3; SHSF3
• NCBI Protein Information: F-box/WD repeat-containing protein 4; dactylin; F-box/WD repeat protein 4; F-box and WD-40 domain protein 4; F-box and WD-40 domain-containing protein 4
• UniProt Protein Name: F-box/WD repeat-containing protein 4
• Protein Family: F-box/WD repeat-containing protein
• UniProt Gene Name: FBXW4
• UniProt Synonym Gene Names: FBW4; SHFM3
• UniProt Entry Name: FBXW4_HUMAN

NCBI Description

This gene is a member of the F-box/WD-40 gene family, which recruit specific target proteins through their WD-40 protein-protein binding domains for ubiquitin mediated degradation. In mouse, a highly similar protein is thought to be responsible for maintaining the apical ectodermal ridge of developing limb buds; disruption of the mouse gene results in the absence of central digits, underdeveloped or absent metacarpal/metatarsal bones and syndactyly. This phenotype is remarkably similar to split hand-split foot malformation in humans, a clinically heterogeneous condition with a variety of modes of transmission. An autosomal recessive form has been mapped to the chromosomal region where this gene is located, and complex rearrangements involving duplications of this gene and others have been associated with the condition. A pseudogene of this locus has been mapped to one of the introns of the BCR gene on chromosome 22. [provided by RefSeq, Jul 2008]

Uniprot Description

FBXW4: Probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation. Likely to be involved in key signaling pathways crucial for normal limb development. May participate in Wnt signaling. Defects in FBXW4 are a cause of split-hand/foot malformation type 3 (SHFM3). SHFM3 is an autosomal dominant disorder characterized by hypoplasia/aplasia of the central digits with fusion of the remaining digits.

Protein type: Cell cycle regulation; Cell development/differentiation

Chromosomal Location of Human Ortholog: 10q24

Cellular Component: ubiquitin ligase complex

Biological Process: ubiquitin-dependent protein catabolic process; Wnt receptor signaling pathway; cartilage development; positive regulation of mesenchymal cell proliferation; embryonic digit morphogenesis; embryonic limb morphogenesis

Disease: Split-hand/foot Malformation 3