Typical Testing Data/Standard Curve (for reference only)
(Fig.1. Human DNA repair protein XRCC2 (XRCC2) Standard Curve.)
Human DNA Repair Protein XRCC2 (XRCC2) ELISA Kit | XRCC2 elisa kit
Human DNA Repair Protein XRCC2 (XRCC2) ELISA Kit
* Allow all reagents to warm to room temperature for at least 30 minutes before opening.
* Pre-rinse the pipet tip with reagent, use fresh pipet tips for each sample, standard and reagent to avoid contamination.
* Unused wells must be kept desiccated at 4 degree C in the sealed bag provided.
* Mix Thoroughly is very important for the result. It is recommended using low frequency oscillator or slight hand shaking every 10 minutes.
* It is recommended that all samples and standards be assayed in duplicate or triplicate.
Typical Testing Data/Standard Curve (for reference only)
(Fig.1. Human DNA repair protein XRCC2 (XRCC2) Standard Curve.)
Typical Testing Data/Standard Curve (for reference only)
(Fig.1. Human DNA repair protein XRCC2 (XRCC2) Standard Curve.)
Background: XRCC2participates in homologous recombination to maintain chromosome stability and repair DNA damage. This gene is involved in the repair of DNA double-strand breaks by homologous recombination and it functionally complements Chinese hamster irs1, a repair-deficient mutant that exhibits hypersensitivity to a number of different DNA-damaging agents.Hamster cells deficient in XRCC2 showed a more than 100-fold decrease in homologous recombination induced by double-strand breaks compared with the parental cell line. This defect was corrected to almost wildtype levels by transient transfection with a plasmid expressing XRCC2. The repair defect in XRCC2 mutant cells appeared to be restricted to recombinational repair because nonhomologous end joining was normal.
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a member of the RecA/Rad51-related protein family that participates in homologous recombination to maintain chromosome stability and repair DNA damage. This gene is involved in the repair of DNA double-strand breaks by homologous recombination and it functionally complements Chinese hamster irs1, a repair-deficient mutant that exhibits hypersensitivity to a number of different DNA-damaging agents. [provided by RefSeq, Jul 2008]
Uniprot Description
XRCC2: Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions. The BCDX2 complex binds single-stranded DNA, single-stranded gaps in duplex DNA and specifically to nicks in duplex DNA. Belongs to the RecA family. RAD51 subfamily.
Chromosomal Location of Human Ortholog: 7q36.1
Cellular Component: centrosome; cytoplasm; replication fork
Molecular Function: DNA-dependent ATPase activity; protein binding; four-way junction DNA binding; ATP binding
Biological Process: meiosis; somitogenesis; positive regulation of neurogenesis; centrosome organization and biogenesis; in utero embryonic development; multicellular organism growth; response to gamma radiation; strand invasion; mitotic cell cycle; negative regulation of neuron apoptosis; DNA repair; double-strand break repair via homologous recombination; response to X-ray
Research Articles on XRCC2
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Product Notes
The Human XRCC2 xrcc2 (Catalog #AAA9713679) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9713679 ELISA Kit recognizes Human XRCC2. It is sometimes possible for the material contained within the vial of "DNA Repair Protein XRCC2 (XRCC2), ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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