Human Cystine/glutamate transporter, SLC7A11 ELISA Kit | SLC7A11 elisa kit
Human Cystine/glutamate transporter, SLC7A11 ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a member of a heteromeric, sodium-independent, anionic amino acid transport system that is highly specific for cysteine and glutamate. In this system, designated Xc(-), the anionic form of cysteine is transported in exchange for glutamate. This protein has been identified as the predominant mediator of Kaposi sarcoma-associated herpesvirus fusion and entry permissiveness into cells. Also, increased expression of this gene in primary gliomas (compared to normal brain tissue) was associated with increased glutamate secretion via the XCT channels, resulting in neuronal cell death. [provided by RefSeq, Sep 2011]
Uniprot Description
SLC7A11: Sodium-independent, high-affinity exchange of anionic amino acids with high specificity for anionic form of cystine and glutamate. Belongs to the amino acid-polyamine-organocation (APC) superfamily. L-type amino acid transporter (LAT) (TC 2.A.3.8) family.
Protein type: Membrane protein, multi-pass; Transporter; Transporter, SLC family; Membrane protein, integral
Chromosomal Location of Human Ortholog: 4q28.3
Cellular Component: cell surface; cytoskeleton; rough endoplasmic reticulum; plasma membrane; integral to membrane
Molecular Function: protein binding; cystine:glutamate antiporter activity
Biological Process: response to nicotine; amino acid transport; response to toxin; ion transport; brain development; response to oxidative stress; blood coagulation; transmembrane transport; leukocyte migration
Research Articles on SLC7A11
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Product Notes
The Human SLC7A11 slc7a11 (Catalog #AAA1606069) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA1606069 ELISA Kit recognizes Human SLC7A11. It is sometimes possible for the material contained within the vial of "Cystine/glutamate transporter, SLC7A11, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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