Human Cyclic AMP-responsive element-binding protein 3-like protein 4 (CREB3L4) ELISA Kit | CREB3L4 elisa kit

Human Cyclic AMP-responsive element-binding protein 3-like protein 4 (CREB3L4) ELISA Kit

Cat. Num. AAA2802248

• Gene Names: CREB3L4; JAL; hJAL; ATCE1; CREB3; CREB4; AIBZIP
• Reactivity: Human
• Synonyms: Cyclic AMP-responsive element-binding protein 3-like protein 4 (CREB3L4); Human Cyclic AMP-responsive element-binding protein 3-like protein 4 (CREB3L4) ELISA Kit; RP11-422P24.8; AIBZIP; ATCE1; CREB3; CREB4; JAL; hJAL; OTTHUMP00000035266|androgen-induced basic leucine zipper|cAMP responsive element binding protein 1; CREB3L4 elisa kit

• Reactivity: Human
• Specificity: This assay has high sensitivity and excellent specificity for detection of Human CREB3L4. No significant cross-reactivity or interference between Human CREB3L4 and analogues was observed.

• Assay Type: Sandwich
• Assay: Serum, Plasma, Other biological fluids
• Analysis Method: Quantitive
• Detection Wavelength: 450nm
• Sample Volume: 1-200uL
• Assay Duration: 1-4.5h
• Precision: Intra-assay Precision (Precision within an assay): Three samples of known concentration were tested twenty times on one plate to assess intra-assay precision.; Inter-assay Precision (Precision between assays); Three samples of known concentration were tested in forty separate assays to assess inter-assay precision.; CV (%) = SD/meanX100; Intra-Assay: CV; Inter-Assay: CV
• Test Principle: This assay employs a two-site sandwich ELISA to quantitate CREB3L4 in samples. An antibody specific for CREB3L4 has been pre-coated onto a microplate. Standards and samples are pipetted into the wells and anyCREB3L4 present is bound by the immobilized antibody. After removing any unbound substances, a biotin-conjugated antibody specific for CREB3L4 is added to the wells. After washing, Streptavidin conjugated Horseradish Peroxidase (HRP) is added to the wells. Following a wash to remove any unbound avidin-enzyme reagent, a substrate solution is added to the wells and color develops in proportion to the amount of CREB3L4 bound in the initial step. The color development is stopped and the intensity of the color is measured.
• Preparation and Storage: Store at 2-8 degree C. Please refer to Instruction Manual.

NCBI and Uniprot Product Information

• NCBI GI #: 18702325
• NCBI GeneID: 148327
• NCBI Accession #: NP_570968.1
• NCBI GenBank Nucleotide #: NM_130898.3
• UniProt Accession #: Q8TEY5; Q5T4L0; Q86YW6; D3DV62
• Molecular Weight: 41,275 Da
• NCBI Official Full Name: cyclic AMP-responsive element-binding protein 3-like protein 4 isoform 1
• NCBI Official Synonym Full Names: cAMP responsive element binding protein 3-like 4
• NCBI Official Symbol: CREB3L4
• NCBI Official Synonym Symbols: JAL; hJAL; ATCE1; CREB3; CREB4; AIBZIP
• NCBI Protein Information: cyclic AMP-responsive element-binding protein 3-like protein 4; CREB-4; tisp40; attaching to CRE-like 1; cAMP responsive element binding protein 1; cAMP-responsive element-binding protein 4; androgen-induced basic leucine zipper protein; cyclic AMP-respon
• UniProt Protein Name: Cyclic AMP-responsive element-binding protein 3-like protein 4
• Protein Family: Cyclic AMP-responsive element-binding protein 3-like protein
• UniProt Gene Name: CREB3L4
• UniProt Synonym Gene Names: AIBZIP; CREB4; JAL; cAMP-responsive element-binding protein 3-like protein 4; AIbZIP; ATCE1; CREB-4; cAMP-responsive element-binding protein 4; Tisp40
• UniProt Entry Name: CR3L4_HUMAN

NCBI Description

This gene encodes a CREB (cAMP responsive element binding) protein with a transmembrane domain which localizes it to the ER membrane. The encoded protein is a transcriptional activator which contains a dimerization domain, and this protein may function in a number of processing pathways including protein processing. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]

Uniprot Description

CREB3L4: Transcriptional activator that may play a role in the unfolded protein response. Binds to the UPR element (UPRE) but not to CRE element. Preferentially binds DNA with to the consensus sequence 5'-T[GT]ACGT[GA][GT]-3' and has transcriptional activation activity from UPRE. Binds to NF-kappa-B site and has transcriptional activation activity from NF-kappa-B-containing regulatory elements. Belongs to the bZIP family. ATF subfamily.

Protein type: Transcription factor; Membrane protein, integral; Endoplasmic reticulum

Chromosomal Location of Human Ortholog: 1q21.3

Cellular Component: Golgi membrane; Golgi apparatus; endoplasmic reticulum membrane; endoplasmic reticulum; integral to membrane; nucleus

Biological Process: transcription, DNA-dependent; unfolded protein response; positive regulation of transcription from RNA polymerase II promoter; spermatogenesis