Human Complement Component 2 (C2) ELISA Kit | C2 elisa kit

Human Complement Component 2 (C2) ELISA Kit

Cat. Num. AAA455686

• Gene Names: C2; CO2; ARMD14
• Reactivity: Human
• Synonyms: Complement Component 2 (C2); Human Complement Component 2 (C2) ELISA Kit; CO2 C3/C5 convertase; C2 elisa kit

• Reactivity: Human
• Sequence Length: 752

• Samples: Serum, plasma and other biological fluids.
• Assay Type: Sandwich
• Detection Range: 0.625-40ng/mL
• Sensitivity: 0.224ng/mL
• Intra Assay: CV<10%
• Inter Assay: CV<12%
• Preparation and Storage: For unopened kit, all reagents should be kept according to the labels on vials. The TMB Substrate, Wash Buffer, Stop Solution should be stored at 4 degree C. All others should be stored at -20 degree C.

Typical Testing Data/Standard Curve (for reference only)

NCBI and Uniprot Product Information

• NCBI GI #: 14550407
• NCBI GeneID: 717
• NCBI Accession #: NP_000054.2
• NCBI GenBank Nucleotide #: NM_000063.5
• UniProt Accession #: P06681; O19694; Q13904; B4DPF3; B4DV20; E9PFN7
• Molecular Weight: 69,444 Da
• NCBI Official Full Name: complement C2 isoform 1 preproprotein
• NCBI Official Synonym Full Names: complement C2
• NCBI Official Symbol: C2
• NCBI Official Synonym Symbols: CO2; ARMD14
• NCBI Protein Information: complement C2
• UniProt Protein Name: Complement C2
• Protein Family: Complement C2
• UniProt Gene Name: C2

NCBI Description

Component C2 is a serum glycoprotein that functions as part of the classical pathway of the complement system. Activated C1 cleaves C2 into C2a and C2b. The serine proteinase C2a then combines with complement factor 4b to create the C3 or C5 convertase. Deficiency of C2 has been reported to associated with certain autoimmune diseases and SNPs in this gene have been associated with altered susceptibility to age-related macular degeneration. This gene localizes within the class III region of the MHC on the short arm of chromosome 6. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional transcript variants have been described in publications but their full-length sequence has not been determined.[provided by RefSeq, Mar 2009]

Uniprot Description

Component C2 which is part of the classical pathway of the complement system is cleaved by activated factor C1 into two fragments: C2b and C2a. C2a, a serine protease, then combines with complement factor C4b to generate the C3 or C5 convertase.