Human Coiled Coil And C2 Domain Containing Protein 1A (CC2D1A) ELISA Kit | CC2D1A elisa kit

Human Coiled Coil And C2 Domain Containing Protein 1A (CC2D1A) ELISA Kit

Cat. Num. AAA167786

• Gene Names: CC2D1A; MRT3; FREUD-1; Freud-1/Aki1
• Reactivity: Human
• Synonyms: Coiled Coil And C2 Domain Containing Protein 1A (CC2D1A); Human Coiled Coil And C2 Domain Containing Protein 1A (CC2D1A) ELISA Kit; CC2D1A elisa kit

• Reactivity: Human
• Sequence Length: 951

• Samples: Serum, plasma, cell culture supernates, cell lysates, tissue homogenates
• Assay Type: Quantitative Sandwich
• Detection Range: 0.05ng/ml - 20ng/ml
• Sensitivity: 0.022ng/ml
• Intra-Assay: CV<8%
• Inter-Assay: CV<10%
• Preparation and Storage: Store at 2 to 8 degree C for 6 months.

Typical Testing Data/Standard Curve (for reference only)

Related Product Information for CC2D1A elisa kit

Intended Uses: This sandwich kit is for the accurate quantitative detection of Human Coiled Coil And C2 Domain Containing Protein 1A (also known as CC2D1A) in serum, plasma, cell culture supernates, cell lysates, tissue homogenates.

Principles of the Assay: This kit is an Enzyme-Linked Immunosorbent Assay (ELISA). The plate has been pre-coated with Human CC2D1A antibody. CC2D1A present in the sample is added and binds to antibodies coated on the wells. And then biotinylated Human CC2D1A Antibody is added and binds to CC2D1A in the sample. Then Streptavidin-HRP is added and binds to the Biotinylated CC2D1A antibody. After incubation unbound Streptavidin-HRP is washed away during a washing step. Substrate solution is then added and color develops in proportion to the amount of Human CC2D1A. The reaction is terminated by addition of acidic stop solution and absorbance is measured at 450 nm.

NCBI and Uniprot Product Information

• NCBI GI #: 96974985
• NCBI GeneID: 54862
• NCBI Accession #: NP_060191.3
• NCBI GenBank Nucleotide #: NM_017721.4
• UniProt Accession #: Q6P1N0; Q7Z435; Q86XV0; Q8NF89; Q9H603; Q9NXI1
• Molecular Weight: 103,934 Da
• NCBI Official Full Name: coiled-coil and C2 domain-containing protein 1A
• NCBI Official Synonym Full Names: coiled-coil and C2 domain containing 1A
• NCBI Official Symbol: CC2D1A
• NCBI Official Synonym Symbols: MRT3; FREUD-1; Freud-1/Aki1
• NCBI Protein Information: coiled-coil and C2 domain-containing protein 1A
• UniProt Protein Name: Coiled-coil and C2 domain-containing protein 1A
• Protein Family: Coiled-coil and C2 domain-containing protein
• UniProt Gene Name: CC2D1A
• UniProt Synonym Gene Names: AKI1; FRE under dual repression-binding protein 1; Freud-1

NCBI Description

This gene encodes a transcriptional repressor that binds to a conserved 14-bp 5'-repressor element and regulates expression of the 5-hydroxytryptamine (serotonin) receptor 1A gene in neuronal cells. The DNA binding and transcriptional repressor activities of the protein are inhibited by calcium. A mutation in this gene results in a nonsyndromic form of cognitive disability (MRT3). [provided by RefSeq, Jul 2017]

Uniprot Description

Transcription factor that binds specifically to the DRE (dual repressor element) and represses HTR1A gene transcription in neuronal cells. The combination of calcium and ATP specifically inactivates the binding with FRE. May play a role in the altered regulation of HTR1A associated with anxiety and major depression. Mediates HDAC-independent repression of HTR1A promoter in neuronal cell. Performs essential function in controlling functional maturation of synapses (). Plays distinct roles depending on its localization. When cytoplasmic, acts as a scaffold protein in the PI3K/PDK1/AKT pathway. Repressor of HTR1A when nuclear. In the centrosome, regulates spindle pole localization of the cohesin subunit SCC1/RAD21, thereby mediating centriole cohesion during mitosis.