Rat: CNTF
The antigens listed below were tested at 50 ng/ml and did not exhibit significant cross reactivity or interference.
Human: BNDF, beta-NGF, GDNF, NT-3, NT-4
Murine: beta-NGF, GDNF
Rat: GDNF
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene is a polypeptide hormone whose actions appear to be restricted to the nervous system where it promotes neurotransmitter synthesis and neurite outgrowth in certain neuronal populations. The protein is a potent survival factor for neurons and oligodendrocytes and may be relevant in reducing tissue destruction during inflammatory attacks. A mutation in this gene, which results in aberrant splicing, leads to ciliary neurotrophic factor deficiency, but this phenotype is not causally related to neurologic disease. A read-through transcript variant composed of the upstream ZFP91 gene and CNTF sequence has been identified, but it is thought to be non-coding. Read-through transcription of ZFP91 and CNTF has also been observed in mouse. [provided by RefSeq, Oct 2010]
Uniprot Description
CNTF: CNTF is a survival factor for various neuronal cell types. Seems to prevent the degeneration of motor axons after axotomy. Belongs to the CNTF family.
Chromosomal Location of Human Ortholog: 11q12.1
Cellular Component: axon; cytoplasm; extracellular region; extracellular space
Molecular Function: ciliary neurotrophic factor receptor binding; cytokine activity; growth factor activity; interleukin-6 receptor binding; protein binding
Biological Process: astrocyte activation; growth; muscle morphogenesis; negative regulation of neuron apoptosis; negative regulation of photoreceptor cell differentiation; neuron development; positive regulation of axon regeneration; positive regulation of cell proliferation; positive regulation of tyrosine phosphorylation of STAT protein; regulation of retinal cell programmed cell death; signal transduction
Research Articles on CNTF
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Product Notes
The Human CNTF cntf (Catalog #AAA9501835) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9501835 ELISA Kit recognizes Human CNTF. It is sometimes possible for the material contained within the vial of "CNTF, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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