Human Chromodomain helicase DNA binding protein 8 (CHD8) ELISA Kit | CHD8 elisa kit
Human Chromodomain helicase DNA binding protein 8 (CHD8) ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a DNA helicase that functions as a transcription repressor by remodeling chromatin structure. It binds beta-catenin and negatively regulates Wnt signaling pathway, which plays a pivotal role in vertebrate early development and morphogenesis. Mice lacking this gene exhibit early embryonic death. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2010]
Uniprot Description
CHD-8: DNA helicase that acts as a chromatin remodeling factor and regulates transcription. Acts as a transcription repressor by remodeling chromatin structure and recruiting histone H1 to target genes. Suppresses p53/TP53-mediated apoptosis by recruiting histone H1 and preventing p53/TP53 transactivation activity. Acts as a negative regulator of Wnt signaling pathway by regulating beta-catenin (CTNNB1) activity. Negatively regulates CTNNB1- targeted gene expression by being recruited specifically to the promoter regions of several CTNNB1 responsive genes. Involved in both enhancer blocking and epigenetic remodeling at chromatin boundary via its interaction with CTCF. Acts as a suppressor of STAT3 activity by suppressing the LIF-induced STAT3 transcriptional activity. Also acts as a transcription activator via its interaction with ZNF143 by participating in efficient U6 RNA polymerase III transcription. Interacts with p53/TP53, histone H1, CTNNB1, CTCF and PIAS3. Component of some MLL1/MLL complex, at least composed of the core components MLL, ASH2L, HCFC1/HCF1, WDR5 and RBBP5, as well as the facultative components C17orf49, CHD8, E2F6, HSP70, INO80C, KANSL1, LAS1L, MAX, MCRS1, MGA, KAT8/MOF, PELP1, PHF20, PRP31, RING2, RUVB1/TIP49A, RUVB2/TIP49B, SENP3, TAF1, TAF4, TAF6, TAF7, TAF9 and TEX10. Interacts with CHD7. Belongs to the SNF2/RAD54 helicase family. CHD8 subfamily. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Transcription factor; Helicase; EC 3.6.4.12
Chromosomal Location of Human Ortholog: 14q11.2
Cellular Component: nucleoplasm; protein complex; nucleus
Molecular Function: DNA-dependent ATPase activity; DNA helicase activity; protein binding; DNA binding; histone binding; p53 binding; beta-catenin binding; chromatin binding; ATP binding; methylated histone residue binding
Biological Process: negative regulation of Wnt receptor signaling pathway; gut development; transcription, DNA-dependent; in utero embryonic development; positive regulation of transcription, DNA-dependent; ATP-dependent chromatin remodeling; positive regulation of transcription from RNA polymerase III promoter; positive regulation of transcription from RNA polymerase II promoter; brain development; negative regulation of transcription from RNA polymerase II promoter; Wnt receptor signaling pathway through beta-catenin; negative regulation of transcription, DNA-dependent; DNA duplex unwinding
Disease: Autism, Susceptibility To, 18
Research Articles on CHD8
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Product Notes
The Human CHD8 chd8 (Catalog #AAA7233217) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA7233217 ELISA Kit recognizes Human CHD8. It is sometimes possible for the material contained within the vial of "Chromodomain helicase DNA binding protein 8 (CHD8), ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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