Typical Testing Data/Standard Curve (for reference only)
Human Calprotectin ELISA Kit
Calprotectin, Human, ELISA kit
Reactivity
Human
Synonyms
Calprotectin; Human; ELISA kit; S100A8/S100A9; MRP8/MRP14; Calprotectin Human ELISA kit 1 x 96 det.; Calprotectin elisa kit
Reactivity
Human
Samples
Feces, plasma, serum, sputum and urine samples. this kit is intended for laboratory research use only and is not for use
Preparation and Storage
Product should be stored at 4 degree C.
Under recommended storage conditions, product is stable for at least six months.
Under recommended storage conditions, product is stable for at least six months.
Typical Testing Data/Standard Curve (for reference only)
Typical Testing Data/Standard Curve (for reference only)
Related Product Information for Calprotectin elisa kit
Intended Uses: The human Calprotectin ELISA kit is to be used for the in vitro quantitative determination of human Calprotectin in feces, plasma, serum, sputum and urine samples. This kit is intended for laboratory research use only. The kit cannot be used for quantification of the individual MRP-8 (S100A8) or MRP-14 (S100A9) proteins. The analysis should be performed by trained laboratory professionals.
Background/Introduction: Calprotectin, also known as MRP-8/MRP-14 or S100A8/A9 heterocomplex, is formed out of the calcium-binding, migration inhibitory factor-related proteins, MRP-8 (S100A8) and MRP-14 (S100A9). The expression of these proteins is largely confined to the cytosol of neutrophils and monocytes. The complex formation of these proteins is calcium-dependent. Calprotectin comprises 60% of the cytoplasmic protein fraction of circulating polymorphonuclear granulocytes and is also found in monocytes, macrophages and ileal tissue eosinophils. Peripheral blood monocytes carry the antigen extra- and intracellularly, neutrophils only intracellularly. Calprotectin has antibacterial, antifungal, immunomodulating and antiproliferative effects. Furthermore, it is a potent chemotactic factor for neutrophils. Plasma concentrations are elevated in diseases associated with increased neutrophil activity. During intestinal wall inflammation, granulocytes transmigrate through the intestinal wall. Therefore Calprotectin is also detectable in feces. Several investigations report that fecal Calprotectin is significantly increased in intestinal diseases such as inflammatory bowel disease (IBD), Crohn´s disease, ulcerative colitis and colon cancer. In the literature it is described that normal human plasma contains a Calprotectin concentration ranging from ~100 to 3,000 ng/ml.
Background/Introduction: Calprotectin, also known as MRP-8/MRP-14 or S100A8/A9 heterocomplex, is formed out of the calcium-binding, migration inhibitory factor-related proteins, MRP-8 (S100A8) and MRP-14 (S100A9). The expression of these proteins is largely confined to the cytosol of neutrophils and monocytes. The complex formation of these proteins is calcium-dependent. Calprotectin comprises 60% of the cytoplasmic protein fraction of circulating polymorphonuclear granulocytes and is also found in monocytes, macrophages and ileal tissue eosinophils. Peripheral blood monocytes carry the antigen extra- and intracellularly, neutrophils only intracellularly. Calprotectin has antibacterial, antifungal, immunomodulating and antiproliferative effects. Furthermore, it is a potent chemotactic factor for neutrophils. Plasma concentrations are elevated in diseases associated with increased neutrophil activity. During intestinal wall inflammation, granulocytes transmigrate through the intestinal wall. Therefore Calprotectin is also detectable in feces. Several investigations report that fecal Calprotectin is significantly increased in intestinal diseases such as inflammatory bowel disease (IBD), Crohn´s disease, ulcerative colitis and colon cancer. In the literature it is described that normal human plasma contains a Calprotectin concentration ranging from ~100 to 3,000 ng/ml.
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Product Notes
The Human Calprotectin (Catalog #AAA584843) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA584843 ELISA Kit recognizes Human Calprotectin. It is sometimes possible for the material contained within the vial of "Calprotectin, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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