Human C3c ELISA Kit | C3c elisa kit
C3c, Human, ELISA kit
Gene Names
c3a.3; c3c; C3-3; c3-2; unp301; zgc:103610
Reactivity
Human
Synonyms
C3c; Human; ELISA kit; C3c Human ELISA kit 1 x 96 det.; C3c elisa kit
Reactivity
Human
Sequence Length
1651
Samples
Serum and plasma
Preparation and Storage
Product should be stored at 4 degree C.
Under recommended storage conditions, product is stable for at least six months.
Under recommended storage conditions, product is stable for at least six months.
Related Product Information for C3c elisa kit
Intended Uses: The human C3c ELISA kit is to be used for the in vitro quantitative determination of human C3c in serum and plasma. This kit is intended for laboratory research use only. The analysis should be performed by trained laboratory professionals.
Background/Introduction: The complement system mediates a number of essential biological functions that participate in host defense against infection, initiation of the inflammatory reaction, processing and clearance of immune complexes and regulation of the immune response. There are three pathways of complement activation: the classical pathway is initiated by immune complexes, the lectin pathway by surface bound mannan binding lectin and the alternative pathway by all the surfaces that are not specifically protected against it. Each complement pathway generates a C3 convertase, a serine protease that cleaves the central complement protein C3, and generates the major cleavage fragment C3b. C3b is an opsonin and part of one of the main convertases that drives the complement cascade. In the presence of complement regulatory molecules C3b may be further degraded sequentially to iC3b, C3c, C3dg and C3d. The disadvantage of most complement biomarkers is their short half-life, making reliable sample collection and measurements difficult. Unlike other C3 fragments, C3c does not bind to other structures like pathogens, cell surface (receptors) and other plasma proteins. Therefore, C3c is a stable complement biomarker which will appear in the fluid phase only, without interference of other C3 based products. The measurement of C3c provides evidence of (uncontrolled) complement activation and can be used as an indicator of an inflammatory state. The complement is a key element of the innate immune system. Inappropriate activation is pathologic and leads for example to various autoimmune diseases (e.g. HUS). There are also indications that C3 is associated with the cardiovascular system and Parkinson's disease, making C3c a reliable and useful biomarker. The C3c ELISA, based on a antibody highly specific for a epitope exclusively on C3c, is a straightforward ELISA which can be used in diseases where complement activation is an element in an inflammatory response.
Background/Introduction: The complement system mediates a number of essential biological functions that participate in host defense against infection, initiation of the inflammatory reaction, processing and clearance of immune complexes and regulation of the immune response. There are three pathways of complement activation: the classical pathway is initiated by immune complexes, the lectin pathway by surface bound mannan binding lectin and the alternative pathway by all the surfaces that are not specifically protected against it. Each complement pathway generates a C3 convertase, a serine protease that cleaves the central complement protein C3, and generates the major cleavage fragment C3b. C3b is an opsonin and part of one of the main convertases that drives the complement cascade. In the presence of complement regulatory molecules C3b may be further degraded sequentially to iC3b, C3c, C3dg and C3d. The disadvantage of most complement biomarkers is their short half-life, making reliable sample collection and measurements difficult. Unlike other C3 fragments, C3c does not bind to other structures like pathogens, cell surface (receptors) and other plasma proteins. Therefore, C3c is a stable complement biomarker which will appear in the fluid phase only, without interference of other C3 based products. The measurement of C3c provides evidence of (uncontrolled) complement activation and can be used as an indicator of an inflammatory state. The complement is a key element of the innate immune system. Inappropriate activation is pathologic and leads for example to various autoimmune diseases (e.g. HUS). There are also indications that C3 is associated with the cardiovascular system and Parkinson's disease, making C3c a reliable and useful biomarker. The C3c ELISA, based on a antibody highly specific for a epitope exclusively on C3c, is a straightforward ELISA which can be used in diseases where complement activation is an element in an inflammatory response.
Product Categories/Family for C3c elisa kit
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
NCBI Official Full Name
complement C3a.3
NCBI Official Synonym Full Names
complement component c3a, duplicate 3
NCBI Official Symbol
c3a.3
NCBI Official Synonym Symbols
c3c; C3-3; c3-2; unp301; zgc:103610
NCBI Protein Information
complement C3a.3; complement component c3a, duplicate 3
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Product Notes
The Human C3c (Catalog #AAA584841) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA584841 ELISA Kit recognizes Human C3c. It is sometimes possible for the material contained within the vial of "C3c, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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