Human C C chemokine receptor like 2 (CCRL2) ELISA Kit | CCRL2 elisa kit
Human C C chemokine receptor like 2 (CCRL2) ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a chemokine receptor like protein, which is predicted to be a seven transmembrane protein and most closely related to CCR1. Chemokines and their receptors mediated signal transduction are critical for the recruitment of effector immune cells to the site of inflammation. This gene is expressed at high levels in primary neutrophils and primary monocytes, and is further upregulated on neutrophil activation and during monocyte to macrophage differentiation. The function of this gene is unknown. This gene is mapped to the region where the chemokine receptor gene cluster is located. [provided by RefSeq, Jul 2008]
Uniprot Description
CCRL2: Receptor for CCL19 and chemerin/RARRES2. Does not appear to be a signaling receptor, but may have a role in modulating chemokine-triggered immune responses by capturing and internalizing CCL19 or by presenting RARRES2 ligand to CMKLR1, a functional signaling receptors. Plays a critical role for the development of Th2 responses. Belongs to the G-protein coupled receptor 1 family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, multi-pass; Receptor, GPCR; GPCR, family 1; Membrane protein, integral
Chromosomal Location of Human Ortholog: 3p21
Cellular Component: integral to plasma membrane; plasma membrane
Molecular Function: CCR chemokine receptor binding; chemokine receptor binding; chemokine receptor activity
Biological Process: G-protein coupled receptor protein signaling pathway; chemotaxis; inflammatory response
Research Articles on CCRL2
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Product Notes
The Human CCRL2 ccrl2 (Catalog #AAA7223379) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA7223379 ELISA Kit recognizes Human CCRL2. It is sometimes possible for the material contained within the vial of "C C chemokine receptor like 2 (CCRL2), ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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