Human BMP-7 ELISA Kit | BMP-7 elisa kit

BMP-7 (Human) OmniKine ELISA Kit

Cat. Num. AAA9502025

• Gene Names: BMP7; OP-1
• Reactivity: Human
• Synonyms: BMP-7; BMP-7 (Human) OmniKine ELISA Kit; Bone morphogenetic protein 7; Osteogenic protein 1; Eptotermin alfa; OP-1; BMP-7 elisa kit

• Reactivity: Human
• Specificity: The OmniKine Human BMP-7 ELISA is capable of recognizing both recombinant and naturally produced Human BMP-7 proteins. The antigens listed below were tested at 50 ng/ml and did not exhibit significant cross-reactivity or interference.; Human: BMP-2, BMP-5, TGF-beta1, BMP-3, BMP-6, TGF-beta2, BMP-4, BMP-8, TGF-beta3
• Form/Format: 12 x 8-Well Microstrips
• Sequence Length: 431

• Samples: Plasma, serum, lysate
• Assay Type: Sandwich ELISA
• Detection Range: 63-4000 pg/ml
• Sensitivity: 63-4000 pg/ml
• Detection Method: Colorimetric 450 nm
• Subtype: None
• Preparation and Storage: Store at 4 degree C for 6 months.

Testing Data

(The OmniKine Human BMP-7 ELISA Kit allows for the detection and quantification of endogenous levels of natural and/or recombinant Human BMP-7 proteins within the range of 63-4000 pg/ml.)

NCBI and Uniprot Product Information

• NCBI GI #: 4502427
• NCBI GeneID: 655
• NCBI Accession #: NP_001710.1
• NCBI GenBank Nucleotide #: NM_001719.2
• UniProt Accession #: P18075; Q9H512; Q9NTQ7
• Molecular Weight: 49,313 Da
• NCBI Official Full Name: bone morphogenetic protein 7 preproprotein
• NCBI Official Synonym Full Names: bone morphogenetic protein 7
• NCBI Official Symbol: BMP7
• NCBI Official Synonym Symbols: OP-1
• NCBI Protein Information: bone morphogenetic protein 7
• UniProt Protein Name: Bone morphogenetic protein 7
• UniProt Gene Name: BMP7
• UniProt Synonym Gene Names: OP1; BMP-7; OP-1

NCBI Description

This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer, which plays a role in bone, kidney and brown adipose tissue development. Additionally, this protein induces ectopic bone formation and may promote fracture healing in human patients. [provided by RefSeq, Jul 2016]

Uniprot Description

BMP7: Induces cartilage and bone formation. May be the osteoinductive factor responsible for the phenomenon of epithelial osteogenesis. Plays a role in calcium regulation and bone homeostasis. Homodimer; disulfide-linked. Interacts with SOSTDC1. Interacts with TWSG1. Expressed in the kidney and bladder. Lower levels seen in the brain. Belongs to the TGF-beta family.

Protein type: Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 20q13.31

Cellular Component: extracellular matrix; extracellular region; extracellular space; vesicle

Molecular Function: cytokine activity; growth factor activity; heparin binding; protein binding; transforming growth factor beta receptor binding

Biological Process: axon guidance; BMP signaling pathway; branching morphogenesis of a tube; cardiac muscle tissue development; cartilage development; dendrite development; embryonic camera-type eye morphogenesis; embryonic limb morphogenesis; embryonic pattern specification; epithelial cell differentiation; epithelial to mesenchymal transition; hindbrain development; mesenchymal cell differentiation; mesoderm formation; mesonephros development; metanephros development; negative regulation of cell cycle; negative regulation of MAP kinase activity; negative regulation of mitosis; negative regulation of neuron differentiation; negative regulation of NF-kappaB import into nucleus; negative regulation of NF-kappaB transcription factor activity; negative regulation of Notch signaling pathway; negative regulation of phosphorylation; negative regulation of transcription, DNA-dependent; neural fold elevation formation; neuron projection morphogenesis; odontogenesis of dentine-containing teeth; ossification; pharyngeal system development; positive regulation of apoptosis; positive regulation of bone mineralization; positive regulation of heterotypic cell-cell adhesion; positive regulation of osteoblast differentiation; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-templated; regulation of apoptosis; response to estradiol; response to peptide hormone; response to vitamin D; skeletal system development; steroid hormone mediated signaling; ureteric bud development