Human BCL-2 ELISA Kit | BCL-2 elisa kit
Phospho-BCL-2 (Thr56) Colorimetric Cell-Based ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
This gene encodes an integral outer mitochondrial membrane protein that blocks the apoptotic death of some cells such as lymphocytes. Constitutive expression of BCL2, such as in the case of translocation of BCL2 to Ig heavy chain locus, is thought to be the cause of follicular lymphoma. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]
Uniprot Description
Bcl-2: a antiapoptotic member of the Bcl-2 family. Regulates cell death by controlling the mitochondrial membrane permeability. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1). Phosphorylation by JNKs may increase its antiapoptotic functions.
Protein type: Apoptosis; Autophagy; Membrane protein, integral; Oncoprotein
Chromosomal Location of Human Ortholog: 18q21.33
Cellular Component: cytoplasm; cytosol; endoplasmic reticulum; endoplasmic reticulum membrane; membrane; mitochondrial outer membrane; mitochondrion; myelin sheath; nuclear membrane; nucleoplasm; nucleus; pore complex; protein complex
Molecular Function: BH3 domain binding; channel activity; channel inhibitor activity; identical protein binding; protease binding; protein binding; protein heterodimerization activity; protein homodimerization activity; protein phosphatase 2A binding; sequence-specific DNA binding; transcription factor binding; ubiquitin protein ligase binding
Biological Process: actin filament organization; apoptosis; axon regeneration; axonogenesis; B cell homeostasis; B cell lineage commitment; B cell proliferation; B cell receptor signaling pathway; behavioral fear response; branching involved in ureteric bud morphogenesis; CD8-positive, alpha-beta T cell lineage commitment; cell aging; cell growth; cellular response to DNA damage stimulus; cellular response to glucose starvation; cellular response to hypoxia; cellular response to organic substance; cochlear nucleus development; defense response to virus; digestive tract morphogenesis; DNA damage response, signal transduction resulting in induction of apoptosis; ear development; endoplasmic reticulum calcium ion homeostasis; female pregnancy; focal adhesion assembly; gland morphogenesis; glomerulus development; hair follicle morphogenesis; homeostasis of number of cells within a tissue; humoral immune response; induction of apoptosis by oxidative stress; induction of apoptosis via death domain receptors; lymphoid progenitor cell differentiation; male gonad development; melanin metabolic process; melanocyte differentiation; mesenchymal cell development; metanephros development; negative regulation of anoikis; negative regulation of apoptosis; negative regulation of apoptotic signaling pathway; negative regulation of autophagy; negative regulation of calcium ion transport into cytosol; negative regulation of cell growth; negative regulation of cell migration; negative regulation of cellular pH reduction; negative regulation of extrinsic apoptotic signaling pathway in absence of ligand; negative regulation of G1/S transition of mitotic cell cycle; negative regulation of intrinsic apoptotic signaling pathway; negative regulation of mitochondrial depolarization; negative regulation of myeloid cell apoptosis; negative regulation of neuron apoptosis; negative regulation of ossification; negative regulation of osteoblast proliferation; negative regulation of reactive oxygen species metabolic process; negative regulation of retinal cell programmed cell death; neuron apoptosis; oocyte development; organ growth; ossification; ovarian follicle development; peptidyl-serine phosphorylation; peptidyl-threonine phosphorylation; pigment granule organization; positive regulation of B cell proliferation; positive regulation of catalytic activity; positive regulation of cell growth; positive regulation of intrinsic apoptotic signaling pathway; positive regulation of melanocyte differentiation; positive regulation of multicellular organism growth; positive regulation of neuron maturation; positive regulation of peptidyl-serine phosphorylation; positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway; positive regulation of skeletal muscle fiber development; positive regulation of smooth muscle cell migration; post-embryonic development; protein amino acid dephosphorylation; protein polyubiquitination; reactive oxygen species metabolic process; regulation of calcium ion transport; regulation of cell-matrix adhesion; regulation of gene expression; regulation of glycoprotein biosynthetic process; regulation of mitochondrial membrane permeability; regulation of mitochondrial membrane potential; regulation of nitrogen utilization; regulation of protein heterodimerization activity; regulation of protein homodimerization activity; regulation of protein stability; regulation of transmembrane transporter activity; regulation of viral genome replication; release of cytochrome c from mitochondria; renal system process; response to cytokine; response to drug; response to gamma radiation; response to glucocorticoid stimulus; response to hydrogen peroxide; response to iron ion; response to nicotine; response to radiation; response to toxin; response to UV-B; spleen development; T cell differentiation in thymus; T cell homeostasis; thymus development
Research Articles on BCL-2
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Product Notes
The Human BCL-2 bcl2 (Catalog #AAA9501407) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9501407 ELISA Kit recognizes Human BCL-2. It is sometimes possible for the material contained within the vial of "BCL-2, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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