Human BCA-1 ELISA Kit | BCA-1 elisa kit

BCA-1 (Human) OmniKine ELISA Kit

Cat. Num. AAA9502043

• Gene Names: CXCL13; BLC; BCA1; ANGIE; BCA-1; BLR1L; ANGIE2; SCYB13
• Reactivity: Human
• Synonyms: BCA-1; BCA-1 (Human) OmniKine ELISA Kit; C-X-C motif chemokine 13; B lymphocyte chemoattractant; CXC chemokine BLC; Small-inducible cytokine B13; Angie; BCA-1 elisa kit

• Reactivity: Human
• Specificity: The OmniKine Human BCA-1 ELISA is capable of recognizing both recombinant and naturally produced Human BCA-1 proteins. The antigens listed below were tested at 50 ng/ml and did not exhibit significant cross-reactivity or interference.; Human: GROalpha, GRObeta, GROgamma, IL-8, IP-10, MIG, SDF-1alpha, SDF-1beta; Murine: SDF-1alpha
• Form/Format: 12 x 8-Well Microstrips
• Sequence Length: 109

• Samples: Plasma, serum, lysate
• Assay Type: Sandwich ELISA
• Detection Range: 16-1000 pg/ml
• Sensitivity: 16-1000 pg/ml
• Detection Method: Colorimetric 450 nm
• Subtype: None
• Preparation and Storage: Store at 4 degree C for 6 months.

Testing Data

(The OmniKine Human BCA-1 ELISA Kit allows for the detection and quantification of endogenous levels of natural and/or recombinant Human BCA-1 proteins within the range of 16-1000 pg/ml.)

NCBI and Uniprot Product Information

• NCBI GI #: 5453577
• NCBI GeneID: 10563
• NCBI Accession #: NP_006410.1
• NCBI GenBank Nucleotide #: NM_006419.2
• UniProt Accession #: O43927
• Molecular Weight: 12,664 Da
• NCBI Official Full Name: C-X-C motif chemokine 13
• NCBI Official Synonym Full Names: C-X-C motif chemokine ligand 13
• NCBI Official Symbol: CXCL13
• NCBI Official Synonym Symbols: BLC; BCA1; ANGIE; BCA-1; BLR1L; ANGIE2; SCYB13
• NCBI Protein Information: C-X-C motif chemokine 13
• UniProt Protein Name: C-X-C motif chemokine 13
• Protein Family: Beta carbonic anhydrase
• UniProt Gene Name: CXCL13
• UniProt Synonym Gene Names: BCA1; BLC; SCYB13; BCA-1

NCBI Description

B lymphocyte chemoattractant, independently cloned and named Angie, is an antimicrobial peptide and CXC chemokine strongly expressed in the follicles of the spleen, lymph nodes, and Peyer's patches. It preferentially promotes the migration of B lymphocytes (compared to T cells and macrophages), apparently by stimulating calcium influx into, and chemotaxis of, cells expressing Burkitt's lymphoma receptor 1 (BLR-1). It may therefore function in the homing of B lymphocytes to follicles. [provided by RefSeq, Oct 2014]

Uniprot Description

CXCL13: Chemotactic for B-lymphocytes but not for T-lymphocytes, monocytes and neutrophils. Does not induce calcium release in B- lymphocytes. Binds to BLR1/CXCR5. Belongs to the intercrine alpha (chemokine CxC) family.

Protein type: Motility/polarity/chemotaxis; Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 4q21.1

Cellular Component: cell; extracellular region; extracellular space

Molecular Function: CCR10 chemokine receptor binding; chemokine activity; CXCR3 chemokine receptor binding; CXCR5 chemokine receptor binding; fibroblast growth factor binding; heparin binding; protein heterodimerization activity; receptor ligand activity

Biological Process: cell surface receptor signaling pathway; cell-cell signaling; chronic inflammatory response; defense response to bacterium; elevation of cytosolic calcium ion concentration; G-protein coupled receptor signaling pathway; germinal center formation; immune response; inflammatory response; lymph node development; lymphocyte chemotaxis across high endothelial venule; positive regulation of cell-cell adhesion mediated by integrin; positive regulation of integrin activation; regulation of angiogenesis; regulation of cell proliferation; regulation of humoral immune response; response to lipopolysaccharide