Human Apoprotein L1 (APO-L1) ELISA Kit | APO-L1 elisa kit

Human Apoprotein L1 (APO-L1) ELISA Kit

Cat. Num. AAA3802780

• Gene Names: APOL1; APOL; APO-L; FSGS4; APOL-I
• Reactivity: Human
• Synonyms: Apoprotein L1 (APO-L1); Human Apoprotein L1 (APO-L1) ELISA Kit; APO-L1 elisa kit

• Reactivity: Human
• Sequence Length: 398

• Samples: Serum, plasma, cell culture supernate and other biological fluids
• Assay Type: Sandwich
• Detection Range: 125ng/ml-2000ng/ml
• Sensitivity: 10 ng/ml

Typical Testing Data/Standard Curve (for reference only)

Related Product Information for APO-L1 elisa kit

Intended Use: The Stop Solution changes the color from blue to yellow and the intensity of the color is measured at 450 nm using a spectrophotometer. In order to measure the concentration ofAPO-L1in the sample, This APO-L1ELISA Kit includes a set of calibration standards. The calibration standards are assayed at the same time as the samples and allow the operator to produce a standard curve of Optical Density versusAPO-L1concentration. The concentration ofAPO-L1in the samples is then determined by comparing the O.D. of the samples to the standard curve.

NCBI and Uniprot Product Information

• NCBI GI #: 211938440
• NCBI GeneID: 8542
• NCBI GenBank Nucleotide #: NP_001130012.1
• UniProt Accession #: O14791
• NCBI Official Full Name: apolipoprotein L1 isoform a
• NCBI Official Synonym Full Names: apolipoprotein L1
• NCBI Official Symbol: APOL1
• NCBI Official Synonym Symbols: APOL; APO-L; FSGS4; APOL-I
• NCBI Protein Information: apolipoprotein L1
• UniProt Protein Name: Apolipoprotein L1
• UniProt Gene Name: APOL1
• UniProt Synonym Gene Names: APOL; Apo-L; ApoL; ApoL-I
• UniProt Entry Name: APOL1_HUMAN

NCBI Description

This gene encodes a secreted high density lipoprotein which binds to apolipoprotein A-I. Apolipoprotein A-I is a relatively abundant plasma protein and is the major apoprotein of HDL. It is involved in the formation of most cholesteryl esters in plasma and also promotes efflux of cholesterol from cells. This apolipoprotein L family member may play a role in lipid exchange and transport throughout the body, as well as in reverse cholesterol transport from peripheral cells to the liver. Several different transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2008]

Uniprot Description

APOL1: May play a role in lipid exchange and transport throughout the body. May participate in reverse cholesterol transport from peripheral cells to the liver. Defects in APOL1 are the cause of focal segmental glomerulosclerosis type 4 (FSGS4). It is a renal pathology defined by the presence of segmental sclerosis in glomeruli and resulting in proteinuria, reduced glomerular filtration rate and edema. Renal insufficiency often progresses to end-stage renal disease, a highly morbid state requiring either dialysis therapy or kidney transplantation. Belongs to the apolipoprotein L family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Secreted, signal peptide; Secreted; Channel, chloride; Lipid-binding

Chromosomal Location of Human Ortholog: 22q13.1

Cellular Component: extracellular space; extracellular region; intrinsic to membrane

Molecular Function: protein binding; chloride channel activity; lipid binding

Biological Process: receptor-mediated endocytosis; cholesterol metabolic process; killing of cells of another organism; cytolysis; innate immune response; lipoprotein metabolic process; chloride transport; lipid transport

Disease: Focal Segmental Glomerulosclerosis 4, Susceptibility To