Human Adenosine Deaminase 2 (ADA) ELISA Kit | ADA elisa kit

Human Adenosine Deaminase 2 (ADA) ELISA Kit

Cat. Num. AAA3802264

• Gene Names: ADA2; PAN; ADGF; CECR1; IDGFL; SNEDS; VAIHS
• Reactivity: Human
• Synonyms: Adenosine Deaminase 2 (ADA); Human Adenosine Deaminase 2 (ADA) ELISA Kit; ADA elisa kit

• Reactivity: Human
• Sequence Length: 511

• Samples: Serum, plasma, cell culture supernate and other biological fluids
• Assay Type: Sandwich
• Detection Range: 4 U/mL-64 U/mL
• Sensitivity: 0.1 U/ml

Typical Testing Data/Standard Curve (for reference only)

Related Product Information for ADA elisa kit

Intended Use: The Stop Solution changes the color from blue to yellow and the intensity of the color is measured at 450 nm using a spectrophotometer. In order to measure the concentration ofADAin the sample, This ADAELISA Kit includes a set of calibration standards. The calibration standards are assayed at the same time as the samples and allow the operator to produce a standard curve of Optical Density versusADAconcentration. The concentration ofADAin the samples is then determined by comparing the O.D. of the samples to the standard curve.

NCBI and Uniprot Product Information

• NCBI GI #: 532691754
• NCBI GeneID: 51816
• NCBI GenBank Nucleotide #: NP_001269154.1
• UniProt Accession #: Q9NZK5
• NCBI Official Full Name: adenosine deaminase 2 isoform a
• NCBI Official Synonym Full Names: adenosine deaminase 2
• NCBI Official Symbol: ADA2
• NCBI Official Synonym Symbols: PAN; ADGF; CECR1; IDGFL; SNEDS; VAIHS
• NCBI Protein Information: adenosine deaminase 2
• UniProt Protein Name: Adenosine deaminase CECR1
• Protein Family: Regulatory protein
• UniProt Gene Name: CECR1
• UniProt Synonym Gene Names: ADA2; ADGF; IDGFL

NCBI Description

This gene encodes a member of a subfamily of the adenosine deaminase protein family. The encoded protein is one of two adenosine deaminases found in humans, which regulate levels of the signaling molecule, adenosine. The encoded protein is secreted from monocytes undergoing differentiation and may regulate cell proliferation and differentiation. This gene may be responsible for some of the phenotypic features associated with cat eye syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]

Uniprot Description

CECR1: Adenosine deaminase that may contribute to the degradation of extracellular adenosine, a signaling molecule that controls a variety of cellular responses. Requires elevated adenosine levels for optimal enzyme activity. Binds to cell surfaces via proteoglycans and may play a role in the regulation of cell proliferation and differentiation, independently of its enzyme activity. Belongs to the adenosine and AMP deaminases family. ADGF subfamily. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 3.5.4.4; Hydrolase; Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 22q11.1

Cellular Component: cytosol; extracellular region; extracellular space

Molecular Function: adenosine deaminase activity; adenosine receptor binding; growth factor activity; protein homodimerization activity; proteoglycan binding; zinc ion binding

Biological Process: adenosine catabolic process; cellular protein metabolic process; hypoxanthine salvage; inosine biosynthetic process

Disease: Polyarteritis Nodosa, Childhood-onset; Sneddon Syndrome