Human TREM-1 (Triggering Receptor Expressed on Myeloid Cells-1) CLIA Kit | TREM-1 clia kit

Human TREM-1 (Triggering Receptor Expressed on Myeloid Cells-1) CLIA Kit

Cat. Num. AAA2532700

• Reactivity: Human
• Synonyms: TREM-1 (Triggering Receptor Expressed on Myeloid Cells-1); Human TREM-1 (Triggering Receptor Expressed on Myeloid Cells-1) CLIA Kit; TREM-1 clia kit

• Reactivity: Human
• Specificity: This kit recognizes natural and recombinant TREM-1. No significant cross-reactivity or interference between TREM-1 and analogues was observed.
• Sequence Length: 230

• Assay Type: Sandwich
• Detection Range: 15.625-1000pg/mL
• Sensitivity: Min: 9.375pg/mL; Max: 1000pg/mL

Typical Testing Data/Standard Curve (for reference only)

Related Product Information for TREM-1 clia kit

Intended Uses: This CLIA kit applies to the in vitro quantitative determination of TREM-1 concentrations in serum, plasma and other biological fluids.

Principle of the Assay: This kit uses Sandwich-CLIA as the method. The micro CLIA plate provided in this kit has been pre-coated with an antibody specific to TREM-1. Standards or samples are added to the appropriate micro CLIA plate wells and combined with the specific antibody. Then a biotinylated detection antibody specific for TREM-1 and Avidin-Horseradish Peroxidase (HRP) conjugate is added to each micro plate well successively and incubated. Free components are washed away. The substrate solution is added to each well. Only those wells that contain TREM-1, biotinylated detection antibody and Avidin-HRP conjugate will appear fluorescence. The Relative light unit (RLU) value is measured spectrophotometrically by the Chemiluminescence immunoassay analyzer. The RLU value is positively associated with the concentration of TREM-1. You can calculate the concentration of TREM-1 in the samples by comparing the RLU value of the samples to the standard curve.

NCBI and Uniprot Product Information

• NCBI GI #: 10946760
• NCBI GeneID: 58217
• NCBI Accession #: NP_067381.1
• NCBI GenBank Nucleotide #: NM_021406.5
• Molecular Weight: 25,409 Da
• NCBI Official Full Name: triggering receptor expressed on myeloid cells 1
• NCBI Official Synonym Full Names: triggering receptor expressed on myeloid cells 1
• NCBI Official Symbol: Trem1
• NCBI Protein Information: triggering receptor expressed on myeloid cells 1
• UniProt Protein Name: Triggering receptor expressed on myeloid cells 1
• UniProt Gene Name: Trem1
• UniProt Synonym Gene Names: TREM-1
• UniProt Entry Name: TREM1_MOUSE

Uniprot Description

TREM1: Stimulates neutrophil and monocyte-mediated inflammatory responses. Triggers release of pro-inflammatory chemokines and cytokines, as well as increased surface expression of cell activation markers. Amplifier of inflammatory responses that are triggered by bacterial and fungal infections and is a crucial mediator of septic shock. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Receptor, misc.; Membrane protein, integral

Cellular Component: membrane; integral to membrane

Biological Process: neutrophil chemotaxis; cell migration; cytokine metabolic process; cytokine secretion during immune response; positive regulation of defense response to virus by host; chemokine metabolic process