Human Integrin Beta 6 (ITGb6) CLIA Kit | ITGb6 clia kit

Human Integrin Beta 6 (ITGb6) CLIA Kit

Cat. Num. AAA2000950

• Gene Names: ITGB6; AI1H
• Reactivity: Human
• Synonyms: Integrin Beta 6 (ITGb6); Human Integrin Beta 6 (ITGb6) CLIA Kit; ITG-B6; ITGb6 clia kit

• Reactivity: Human
• Specificity: This assay has high sensitivity and excellent specificity for detection of Integrin Beta 6 (ITGb6).; No significant cross-reactivity or interference between Integrin Beta 6 (ITGb6) and analogues was observed.
• Sequence Length: 788

• Assay Type: Double-antibody Sandwich
• Samples: Tissue homogenates, Cell lysates and Other Biological Fluids
• Detection Range: 13.7-10,000pg/mL
• Sensitivity: < 4.9pg/mL
• Application: Chemiluminescent immunoassay for Antigen Detection.
• Intra-assay Precision (Precision within an assay): 3 samples with low, middle and high level Integrin Beta 6 (ITGb6) were tested 20 times on one plate, respectively.
• Inter-assay Precision (Precision between assays): 3 samples with low, middle and high level Integrin Beta 6 (ITGb6) were tested on 3 different plates, 8 replicates in each plate.
• CV(%) =: SD/meanX100
• Intra-Assay: CV<10%
• Inter-Assay: CV<12%
• Preparation and Storage: The stability of kit is determined by the loss rate of activity. The loss rate of this kit is less than 5% within the expiration date under appropriate storage condition. ; To minimize extra influence on the performance, operation procedures and lab conditions, especially room temperature, air humidity, incubator temperature should be strictly controlled. It is also strongly suggested that the whole assay is performed by the same operator from the beginning to the end.

Typical Testing Data/Standard Curve (for reference only)

Related Product Information for ITGb6 clia kit

The microplate provided in this kit has been pre-coated with an antibody specific to Integrin Beta 6 (ITGb6). Standards or samples are then added to the appropriate microplate wells with a biotin-conjugated antibody specific to Integrin Beta 6 (ITGb6). Next, Avidin conjugated to Horseradish Peroxidase (HRP) is added to each microplate well and incubated. Then the mixture of substrate A and B is added to generate glow light emission kinetics. Upon plate development, the intensity of the emitted light is proportional to the Integrin Beta 6 (ITGb6) level in the sample or standard.;

Product Categories/Family for ITGb6 clia kit

Signal transduction; CD & Adhesion molecule

NCBI and Uniprot Product Information

• NCBI GI #: 538916664
• NCBI GeneID: 3694
• NCBI Accession #: NP_001269282.1
• NCBI GenBank Nucleotide #: NM_001282353.1
• UniProt Accession #: P18564; Q0VA95; Q16500; Q53RG5; Q53RR6; B2R9W5; C9JA97
• Molecular Weight: 74,958 Da
• NCBI Official Full Name: integrin beta-6 isoform a
• NCBI Official Synonym Full Names: integrin, beta 6
• NCBI Official Symbol: ITGB6
• NCBI Official Synonym Symbols: AI1H
• NCBI Protein Information: integrin beta-6
• UniProt Protein Name: Integrin beta-6
• Protein Family: Integrin
• UniProt Gene Name: ITGB6
• UniProt Entry Name: ITB6_HUMAN

NCBI Description

This gene encodes a protein that is a member of the integrin superfamily. Members of this family are adhesion receptors that function in signaling from the extracellular matrix to the cell. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. The encoded protein forms a dimer with an alpha v chain and this heterodimer can bind to ligands like fibronectin and transforming growth factor beta 1. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]

Uniprot Description

ITGB6: Integrin alpha-V/beta-6 is a receptor for fibronectin and cytotactin. It recognizes the sequence R-G-D in its ligands. Internalisation of integrin alpha-V/beta-6 via clathrin-mediated endocytosis promotes carcinoma cell invasion. Belongs to the integrin beta chain family.

Protein type: Membrane protein, integral; Motility/polarity/chemotaxis; Cell adhesion

Chromosomal Location of Human Ortholog: 2q24.2

Cellular Component: plasma membrane; integrin complex; receptor complex; external side of plasma membrane

Molecular Function: integrin binding; viral receptor activity

Biological Process: integrin-mediated signaling pathway; extracellular matrix organization and biogenesis; entry of virus into host cell; multicellular organismal development; cell-matrix adhesion; cell adhesion; inflammatory response

Disease: Amelogenesis Imperfecta, Type Ih