Human Insulin Like Growth Factor Binding Protein 7 (IGFBP7) CLIA Kit | IGFBP7 clia kit

Human Insulin Like Growth Factor Binding Protein 7 (IGFBP7) CLIA Kit

Cat. Num. AAA2000987

• Gene Names: IGFBP7; AGM; PSF; TAF; FSTL2; IBP-7; MAC25; IGFBP-7; RAMSVPS; IGFBP-7v; IGFBPRP1
• Reactivity: Human
• Synonyms: Insulin Like Growth Factor Binding Protein 7 (IGFBP7); Human Insulin Like Growth Factor Binding Protein 7 (IGFBP7) CLIA Kit; FSTL2; IGFBP-7v; MAC25; PSF; TAF; IGFBP-rP1; MAC25 protein; Prostacyclin-stimulating factor; PGI2-stimulating factor; Tumor-derived adhesion factor; IGFBP7 clia kit

• Reactivity: Human
• Specificity: This assay has high sensitivity and excellent specificity for detection of Insulin Like Growth Factor Binding Protein 7 (IGFBP7).; No significant cross-reactivity or interference between Insulin Like Growth Factor Binding Protein 7 (IGFBP7) and analogues was observed.
• Sequence Length: 282

• Assay Type: Double-antibody Sandwich
• Samples: Serum, Plasma and Other Biological Fluids
• Detection Range: 0.82-600ng/mL
• Sensitivity: < 0.31ng/mL
• Application: Chemiluminescent immunoassay for Antigen Detection.
• Intra-assay Precision (Precision within an assay): 3 samples with low, middle and high level Insulin Like Growth Factor Binding Protein 7 (IGFBP7) were tested 20 times on one plate, respectively.
• Inter-assay Precision (Precision between assays): 3 samples with low, middle and high level Insulin Like Growth Factor Binding Protein 7 (IGFBP7) were tested on 3 different plates, 8 replicates in each plate.
• CV(%) =: SD/meanX100
• Intra-Assay: CV<10%
• Inter-Assay: CV<12%
• Preparation and Storage: The stability of kit is determined by the loss rate of activity. The loss rate of this kit is less than 5% within the expiration date under appropriate storage condition. ; To minimize extra influence on the performance, operation procedures and lab conditions, especially room temperature, air humidity, incubator temperature should be strictly controlled. It is also strongly suggested that the whole assay is performed by the same operator from the beginning to the end.

Typical Testing Data/Standard Curve (for reference only)

Related Product Information for IGFBP7 clia kit

The microplate provided in this kit has been pre-coated with an antibody specific to Insulin Like Growth Factor Binding Protein 7 (IGFBP7). Standards or samples are then added to the appropriate microplate wells with a biotin-conjugated antibody specific to Insulin Like Growth Factor Binding Protein 7 (IGFBP7). Next, Avidin conjugated to Horseradish Peroxidase (HRP) is added to each microplate well and incubated. Then the mixture of substrate A and B is added to generate glow light emission kinetics. Upon plate development, the intensity of the emitted light is proportional to the Insulin Like Growth Factor Binding Protein 7 (IGFBP7) level in the sample or standard.;

Product Categories/Family for IGFBP7 clia kit

Metabolic pathway

NCBI and Uniprot Product Information

• NCBI GI #: 4504619
• NCBI GeneID: 3490
• NCBI Accession #: NP_001544.1
• NCBI GenBank Nucleotide #: NM_001553.2
• UniProt Accession #: Q16270; Q07822; Q53YE6; Q9UCA8; B4E1N2; B7Z9W7
• Molecular Weight: 28,860 Da
• NCBI Official Full Name: insulin-like growth factor-binding protein 7 isoform 1
• NCBI Official Synonym Full Names: insulin-like growth factor binding protein 7
• NCBI Official Symbol: IGFBP7
• NCBI Official Synonym Symbols: AGM; PSF; TAF; FSTL2; IBP-7; MAC25; IGFBP-7; RAMSVPS; IGFBP-7v; IGFBPRP1
• NCBI Protein Information: insulin-like growth factor-binding protein 7
• UniProt Protein Name: Insulin-like growth factor-binding protein 7
• Protein Family: Insulin-like growth factor-binding protein
• UniProt Gene Name: IGFBP7
• UniProt Synonym Gene Names: MAC25; PSF; IBP-7; IGF-binding protein 7; IGFBP-7; TAF
• UniProt Entry Name: IBP7_HUMAN

NCBI Description

This gene encodes a member of the insulin-like growth factor (IGF)-binding protein (IGFBP) family. IGFBPs bind IGFs with high affinity, and regulate IGF availability in body fluids and tissues and modulate IGF binding to its receptors. This protein binds IGF-I and IGF-II with relatively low affinity, and belongs to a subfamily of low-affinity IGFBPs. It also stimulates prostacyclin production and cell adhesion. Alternatively spliced transcript variants encoding different isoforms have been described for this gene, and one variant has been associated with retinal arterial macroaneurysm (PMID:21835307). [provided by RefSeq, Dec 2011]

Uniprot Description

IGFBP7: Binds IGF-I and IGF-II with a relatively low affinity. Stimulates prostacyclin (PGI2) production. Stimulates cell adhesion. Defects in IGFBP7 are the cause of retinal arterial macroaneurysm with supravalvular pulmonic stenosis (RAMSVPS). RAMSVPS is an autosomal recessive condition characterized by the bilateral appearance of 'beading' along the major retinal arterial trunks, with the subsequent formation of macroaneurysms. Affected individuals also have supravalvular pulmonic stenosis, often requiring surgical correction.

Protein type: Cell cycle regulation; Secreted; Cell adhesion; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 4q12

Cellular Component: extracellular matrix; extracellular space; extracellular region

Molecular Function: insulin-like growth factor binding; protein binding

Biological Process: negative regulation of cell proliferation; response to retinoic acid; response to cortisol stimulus; response to heat; regulation of steroid biosynthetic process; regulation of cell growth; cell adhesion; inner ear development; embryo implantation; cellular response to hormone stimulus

Disease: Retinal Arterial Macroaneurysm With Supravalvular Pulmonic Stenosis