Human CXCR3 (Chemokine CXC Receptor 3) CLIA Kit | CXCR3 clia kit

Human CXCR3 (Chemokine CXC Receptor 3) CLIA Kit

Cat. Num. AAA2532651

• Gene Names: Cxcr3; Cd183; Cmkar3
• Reactivity: Human
• Synonyms: CXCR3 (Chemokine CXC Receptor 3); Human CXCR3 (Chemokine CXC Receptor 3) CLIA Kit; CXCR3 clia kit

• Reactivity: Human
• Specificity: This kit recognizes natural and recombinant CXCR3. No significant cross-reactivity or interference between CXCR3 and analogues was observed.
• Sequence Length: 367

• Assay Type: Sandwich
• Detection Range: 31.25-2000pg/mL
• Sensitivity: Min: 18.75pg/mL; Max: 2000pg/mL

Typical Testing Data/Standard Curve (for reference only)

Related Product Information for CXCR3 clia kit

Intended Uses: This CLIA kit applies to the in vitro quantitative determination of CXCR3 concentrations in serum, plasma and other biological fluids.

Principle of the Assay: This kit uses Sandwich-CLIA as the method. The micro CLIA plate provided in this kit has been pre-coated with an antibody specific to CXCR3. Standards or samples are added to the appropriate micro CLIA plate wells and combined with the specific antibody. Then a biotinylated detection antibody specific for CXCR3 and Avidin-Horseradish Peroxidase (HRP) conjugate is added to each micro plate well successively and incubated. Free components are washed away. The substrate solution is added to each well. Only those wells that contain CXCR3, biotinylated detection antibody and Avidin-HRP conjugate will appear fluorescence. The Relative light unit (RLU) value is measured spectrophotometrically by the Chemiluminescence immunoassay analyzer. The RLU value is positively associated with the concentration of CXCR3. You can calculate the concentration of CXCR3 in the samples by comparing the RLU value of the samples to the standard curve.

NCBI and Uniprot Product Information

• NCBI GI #: 6753458
• NCBI GeneID: 12766
• NCBI Accession #: NP_034040.1
• NCBI GenBank Nucleotide #: NM_009910.3
• Molecular Weight: 41,018 Da
• NCBI Official Full Name: C-X-C chemokine receptor type 3
• NCBI Official Synonym Full Names: chemokine (C-X-C motif) receptor 3
• NCBI Official Symbol: Cxcr3
• NCBI Official Synonym Symbols: Cd183; Cmkar3
• NCBI Protein Information: C-X-C chemokine receptor type 3
• UniProt Protein Name: C-X-C chemokine receptor type 3
• Protein Family: C-X-C chemokine receptor
• UniProt Gene Name: Cxcr3
• UniProt Synonym Gene Names: Cmkar3; CXC-R3; CXCR-3; IP-10 receptor
• UniProt Entry Name: CXCR3_MOUSE

NCBI Description

This gene encodes a transmembrane protein that functions as a receptor for C-X-R chemokines. Signalling through this protein regulates a variety of biological processes, including inflammation, immunity, and would healing. This protein also plays a role in tumor growth and metastasis. [provided by RefSeq, May 2015]

Uniprot Description

CXCR3: Receptor for CXCL9, CXCL10 and CXCL11 and mediates the proliferation of human mesangial cells (HMC). Belongs to the G-protein coupled receptor 1 family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR; GPCR, family 1

Cellular Component: cell surface; membrane; plasma membrane; integral to membrane; intracellular; cytosol; external side of plasma membrane

Molecular Function: G-protein coupled receptor activity; C-X-C chemokine binding; signal transducer activity; chemokine receptor activity; chemokine binding; receptor activity; C-X-C chemokine receptor activity

Biological Process: positive regulation of chemotaxis; calcium-mediated signaling; positive regulation of cAMP metabolic process; signal transduction; chemotaxis; G-protein coupled receptor protein signaling pathway; negative regulation of angiogenesis; positive regulation of angiogenesis; elevation of cytosolic calcium ion concentration; cell surface receptor linked signal transduction; negative regulation of endothelial cell proliferation; regulation of leukocyte migration; positive regulation of cell proliferation; positive regulation of transcription from RNA polymerase II promoter; angiogenesis; positive regulation of release of sequestered calcium ion into cytosol; inflammatory response